Abstract：
Cardiac amyloidosis (CA) is caused by the myocardial deposition of misfolded proteins, either amyloid transthyretin (ATTR) or immunoglobulin light chains (AL). The paradigm of this condition has transformed, since CA is increasingly recognized as a relatively prevalent cause of heart failure. Cardiac scintigraphy with bone tracers is the unique noninvasive technique able to confirm CA without performing tissue biopsy or advanced imaging tests. A moderate-to-intense myocardial uptake (Perugini grade ≥2) associated with the absence of a monoclonal component is greater than 99% specific for ATTR-CA, while AL-CA confirmation requires tissue biopsy.
摘要：
心脏淀粉样变性（CA）是由错误折叠蛋白的心肌沉积引起的，淀粉样蛋白转甲状腺素蛋白（ATTR）或免疫球蛋白轻链（AL）。这种情况的范式已经转变，由于CA越来越被认为是心力衰竭的相对普遍原因。带有骨示踪剂的心脏闪烁显像是一种独特的非侵入性技术，能够在不进行组织活检或高级影像学检查的情况下确认CA。与缺乏单克隆成分相关的中度至重度心肌摄取（Perugini等级≥2）对ATTR-CA的特异性大于99％，而AL-CA确认需要组织活检。
