Abstract：
During the last decades, the ever-increasing incidence of diseases has led to high rates of mortality throughout the world. On the other hand, the inability and deficiencies of conventional approaches (such as chemotherapy) in the suppression of diseases remain challenging issues. As a result, there is a fundamental requirement to develop novel, biocompatible, bioavailable, and practical nanomaterials to prevent the incidence and mortality of diseases. Chitosan (CS) derivatives and their blends are outstandingly employed as promising drug delivery systems for disease therapy. These biopolymers are indicated more efficient performance against diseases compared with conventional modalities. The CS blends possess improved physicochemical properties, ease of preparation, high affordability, etc. characteristics compared with other biopolymers and even pure CS which result in efficient thermal, mechanical, biochemical, and biomedical features. Also, these blends can be administrated through different routes without a long-term treatment period. Due to the mentioned properties, numerous formulations of CS blends are developed for pharmaceutical sciences to treat diseases. This review article highlights the progressions in the development of CS-based blends as potential drug delivery systems against diseases.
摘要：
在过去的几十年里，疾病发病率的不断增加导致全世界的高死亡率。另一方面,传统方法(如化疗)在抑制疾病方面的能力和不足仍然是具有挑战性的问题.因此,发展小说有一个基本要求，生物相容性生物可利用，和实用的纳米材料来预防疾病的发生和死亡。壳聚糖(CS)衍生物及其共混物被显著地用作用于疾病治疗的有前景的药物递送系统。与常规方式相比，这些生物聚合物显示出更有效的抗病性能。CS共混物具有改善的物理化学性能，易于准备,高承受能力，等。与其他生物聚合物，甚至是纯CS相比，导致有效的热特性，机械,生物化学，和生物医学特征。此外，这些混合物可以通过不同的途径给药，而无需长期治疗期。由于上述属性，CS共混物的许多配方被开发用于药物科学以治疗疾病。本文重点介绍了基于CS的混合物作为潜在的疾病给药系统的开发进展。
