Abstract：
OBJECTIVE: Immunity alterations have been observed in bipolar disorder (BD). However, whether serum positivity of antibodies to Toxoplasma gondii (T gondii), rubella, and cytomegalovirus (CMV) shared clinical relevance with BD, remains controversial. This study aimed to investigate this association.
METHODS: Antibody seropositivity of IgM and IgG to T gondii, rubella virus, and CMV of females with BD and controls was extracted based on medical records from January 2018 to January 2023. Family history, type of BD, onset age, and psychotic symptom history were also collected.
RESULTS: 585 individuals with BD and 800 healthy controls were involved. Individuals with BD revealed a lower positive rate of T gondii IgG in the 10-20 aged group (OR = 0.10), and a higher positive rate of rubella IgG in the 10-20 (OR = 5.44) and 20-30 aged group (OR = 3.15). BD with family history preferred a higher positive rate of T gondii IgG (OR = 24.00). Type-I BD owned a decreased positive rate of rubella IgG (OR = 0.37) and an elevated positive rate of CMV IgG (OR = 2.12) compared to type-II BD, while BD with early onset showed contrast results compared to BD without early onset (Rubella IgG, OR = 2.54; CMV IgG, OR = 0.26). BD with psychotic symptom history displayed a lower positive rate of rubella IgG (OR = 0.50).
CONCLUSIONS: Absence of male evidence and control of socioeconomic status and environmental exposure.
CONCLUSIONS: Differential antibody seropositive rates of T gondii, rubella, and cytomegalovirus in BD were observed.
METHODS: Antibody seropositivity of IgM and IgG to T gondii, rubella virus, and CMV of females with BD and controls was extracted based on medical records from January 2018 to January 2023. Family history, type of BD, onset age, and psychotic symptom history were also collected.
RESULTS: 585 individuals with BD and 800 healthy controls were involved. Individuals with BD revealed a lower positive rate of T gondii IgG in the 10-20 aged group (OR = 0.10), and a higher positive rate of rubella IgG in the 10-20 (OR = 5.44) and 20-30 aged group (OR = 3.15). BD with family history preferred a higher positive rate of T gondii IgG (OR = 24.00). Type-I BD owned a decreased positive rate of rubella IgG (OR = 0.37) and an elevated positive rate of CMV IgG (OR = 2.12) compared to type-II BD, while BD with early onset showed contrast results compared to BD without early onset (Rubella IgG, OR = 2.54; CMV IgG, OR = 0.26). BD with psychotic symptom history displayed a lower positive rate of rubella IgG (OR = 0.50).
CONCLUSIONS: Absence of male evidence and control of socioeconomic status and environmental exposure.
CONCLUSIONS: Differential antibody seropositive rates of T gondii, rubella, and cytomegalovirus in BD were observed.
摘要：
目的：已在双相情感障碍（BD）中观察到免疫改变。然而,弓形虫（Tgondii）抗体的血清阳性，风疹,巨细胞病毒（CMV）与BD具有临床相关性，仍然有争议。本研究旨在探讨这种关联。
方法：弓形虫的抗体血清阳性，风疹病毒,CMVIgM,根据病历(2018年1月至2023年1月)提取了女性BD患者和对照组的IgG.家族史,BD类型,发病年龄,并收集精神病症状史。
结果：585名BD患者和800名健康对照。BD患者在10-20岁组发现弓形虫IgG阳性率较低（OR=0.10），风疹IgG阳性率在10-20岁组(OR=5.44)和20-30岁组(OR=3.15)较高。有家族史的BD优选弓形虫IgG阳性率较高(OR=24.00)。与II型BD相比，I型BD的风疹IgG阳性率降低（OR=0.37），CMVIgG阳性率升高（OR=2.12）。而早期发作的BD与无早期发作的BD相比显示出对比结果(风疹IgG，OR=2.54；CMVIgG，OR=0.26）。有精神病症状史的BD显示风疹IgG阳性率较低（OR=0.50）。
结论：缺乏男性证据和控制社会经济地位和环境暴露。
结论：弓形虫的差异抗体阳性率，风疹,在BD中观察到巨细胞病毒。
方法：弓形虫的抗体血清阳性，风疹病毒,CMVIgM,根据病历(2018年1月至2023年1月)提取了女性BD患者和对照组的IgG.家族史,BD类型,发病年龄,并收集精神病症状史。
结果：585名BD患者和800名健康对照。BD患者在10-20岁组发现弓形虫IgG阳性率较低（OR=0.10），风疹IgG阳性率在10-20岁组(OR=5.44)和20-30岁组(OR=3.15)较高。有家族史的BD优选弓形虫IgG阳性率较高(OR=24.00)。与II型BD相比，I型BD的风疹IgG阳性率降低（OR=0.37），CMVIgG阳性率升高（OR=2.12）。而早期发作的BD与无早期发作的BD相比显示出对比结果(风疹IgG，OR=2.54；CMVIgG，OR=0.26）。有精神病症状史的BD显示风疹IgG阳性率较低（OR=0.50）。
结论：缺乏男性证据和控制社会经济地位和环境暴露。
结论：弓形虫的差异抗体阳性率，风疹,在BD中观察到巨细胞病毒。
