PDF(Pubmed)
Abstract：
The atypical cadherins Fat and Dachsous (Ds) signal through the Hippo pathway to regulate growth of numerous organs, including the Drosophila wing. Here, we find that Ds-Fat signaling tunes a unique feature of cell proliferation found to control the rate of wing growth during the third instar larval phase. The duration of the cell cycle increases in direct proportion to the size of the wing, leading to linear-like growth during the third instar. Ds-Fat signaling enhances the rate at which the cell cycle lengthens with wing size, thus diminishing the rate of wing growth. We show that this results in a complex but stereotyped relative scaling of wing growth with body growth in Drosophila. Finally, we examine the dynamics of Fat and Ds protein distribution in the wing, observing graded distributions that change during growth. However, the significance of these dynamics is unclear since perturbations in expression have negligible impact on wing growth.
摘要：
非典型钙黏着蛋白Fat和Dachsous（Ds）通过Hippo途径发出信号，以调节许多器官的生长，包括果蝇的翅膀.这里,我们发现Ds-Fat信号调节了细胞增殖的独特特征，该特征被发现可以控制三龄幼虫期的机翼生长速率。细胞周期的持续时间与机翼的大小成正比，导致第三龄的线性生长。Ds-Fat信号传导增强了细胞周期随着机翼大小而延长的速率，从而降低机翼生长的速度。我们表明，这会导致果蝇的翅膀生长与身体生长的复杂但刻板的相对比例。最后,我们检查了机翼中脂肪和Ds蛋白质分布的动力学，观察生长过程中变化的分级分布。然而,这些动力学的意义尚不清楚，因为表达中的扰动对机翼生长的影响可以忽略不计。
