Abstract：
Tumor lysis syndrome (TLS) is a life-threatening metabolic disorder caused by massive tumor lysis. Allopurinol, a xanthine oxidase inhibitor, is initiated during chemotherapy to prevent hyperuricemia and subsequent acute kidney injury (AKI). We report two cases of xanthine nephrolithiasis during TLS in newly diagnosed hematologic malignancy patients receiving prophylactic allopurinol. Allopurinol use likely promoted xanthine crystallization, stone formation, and AKI.
摘要：
肿瘤溶解综合征（TLS）是由大量肿瘤溶解引起的危及生命的代谢紊乱。别嘌呤醇,黄嘌呤氧化酶抑制剂,在化疗期间开始，以预防高尿酸血症和随后的急性肾损伤（AKI）。我们报告了在接受预防性别嘌呤醇的新诊断的血液系统恶性肿瘤患者中，TLS期间发生了两例黄嘌呤肾结石。别嘌呤醇的使用可能促进黄嘌呤结晶，岩层,AKI。
