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Abstract：
BACKGROUND: High-sensitivity troponin I (hs-cTnI) and T (hs-cTnT) provide complementary information regarding cardiovascular disease risk. The explanation for their distinct risk profiles is incompletely understood.
RESULTS: hs-cTnI and hs-cTnT were measured in Dallas Heart Study participants. Associations of hs-cTnI and hs-cTnT with demographics and phenotypes were assessed using linear regression. Associations with incident heart failure, atherosclerotic cardiovascular disease, global cardiovascular disease, and cardiovascular and all-cause mortality were assessed using Cox models. Among 3276 participants (56% women, 50% Black persons, median age 43 years), the correlation between hs-cTnI and hs-cTnT was modest (Spearman rho=0.35). Variables associated with hs-cTnI but not hs-cTnT included hypertension, higher body mass index and total cholesterol, and lower high-density lipoprotein and cholesterol efflux capacity. Older age, male sex, and diabetes were positively associated, and smoking was negatively associated, with hs-cTnT but not hs-cTnI. Hs-cTnI and hs-cTnT were associated with heart failure (hazard ratio [HR] per SD log hs-cTnI 1.53 [95% CI, 1.30-1.81] and HR per SD log hs-cTnT 1.65 [95% CI, 1.40-1.95]), global cardiovascular disease (HR, 1.22 [95% CI, 1.10-1.34] and HR, 1.27 [95% CI, 1.15-1.32]), and all-cause mortality (HR, 1.12 [95% CI, 1.01-1.25], and HR, 1.17 [95% CI, 1.06-1.29]). After adjustment for N-terminal pro-B-type natriuretic peptide and the alternative troponin, both remained associated with heart failure (HR per SD log hs-cTnI 1.32 [95% CI, 1.1-1.58] and HR per log hs-cTnT 1.27 [95% CI, 1.06-1.51]).
CONCLUSIONS: Hs-cTnI and hs-cTnT are modestly correlated, demonstrate differential associations with cardiac and metabolic phenotypes, and provide complementary information regarding heart failure risk.
RESULTS: hs-cTnI and hs-cTnT were measured in Dallas Heart Study participants. Associations of hs-cTnI and hs-cTnT with demographics and phenotypes were assessed using linear regression. Associations with incident heart failure, atherosclerotic cardiovascular disease, global cardiovascular disease, and cardiovascular and all-cause mortality were assessed using Cox models. Among 3276 participants (56% women, 50% Black persons, median age 43 years), the correlation between hs-cTnI and hs-cTnT was modest (Spearman rho=0.35). Variables associated with hs-cTnI but not hs-cTnT included hypertension, higher body mass index and total cholesterol, and lower high-density lipoprotein and cholesterol efflux capacity. Older age, male sex, and diabetes were positively associated, and smoking was negatively associated, with hs-cTnT but not hs-cTnI. Hs-cTnI and hs-cTnT were associated with heart failure (hazard ratio [HR] per SD log hs-cTnI 1.53 [95% CI, 1.30-1.81] and HR per SD log hs-cTnT 1.65 [95% CI, 1.40-1.95]), global cardiovascular disease (HR, 1.22 [95% CI, 1.10-1.34] and HR, 1.27 [95% CI, 1.15-1.32]), and all-cause mortality (HR, 1.12 [95% CI, 1.01-1.25], and HR, 1.17 [95% CI, 1.06-1.29]). After adjustment for N-terminal pro-B-type natriuretic peptide and the alternative troponin, both remained associated with heart failure (HR per SD log hs-cTnI 1.32 [95% CI, 1.1-1.58] and HR per log hs-cTnT 1.27 [95% CI, 1.06-1.51]).
CONCLUSIONS: Hs-cTnI and hs-cTnT are modestly correlated, demonstrate differential associations with cardiac and metabolic phenotypes, and provide complementary information regarding heart failure risk.
摘要：
背景：高敏肌钙蛋白I（hs-cTnI）和T（hs-cTnT）提供了有关心血管疾病风险的补充信息。对其独特风险特征的解释尚不完全清楚。
结果：在达拉斯心脏研究参与者中测量hs-cTnI和hs-cTnT。使用线性回归评估hs-cTnI和hs-cTnT与人口统计学和表型的关联。与心力衰竭相关，动脉粥样硬化性心血管疾病，全球心血管疾病，使用Cox模型评估心血管和全因死亡率.在3276名参与者中（56%为女性，50%的黑人中位年龄43岁)，hs-cTnI和hs-cTnT之间的相关性中等(Spearmanrho=0.35)。与hs-cTnI相关但与hs-cTnT无关的变量包括高血压，较高的体重指数和总胆固醇，降低高密度脂蛋白和胆固醇的流出能力。年纪大了,男性,和糖尿病呈正相关，和吸烟呈负相关，与hs-cTnT，但不是hs-cTnI。Hs-cTnI和hs-cTnT与心力衰竭相关(风险比[HR]每SDloghs-cTnI1.53[95%CI,1.30-1.81]和HR每SDloghs-cTnT1.65[95%CI,1.40-1.95]),全球心血管疾病(HR，1.22[95%CI，1.10-1.34]和HR，1.27[95%CI，1.15-1.32])，和全因死亡率(HR，1.12[95%CI，1.01-1.25]，HR,1.17[95%CI，1.06-1.29]）。调整N末端B型利钠肽前体和替代肌钙蛋白后，两者均与心力衰竭相关(HR/SDloghs-cTnI1.32[95%CI,1.1-1.58]和HR/loghs-cTnT1.27[95%CI,1.06-1.51]).
结论：Hs-cTnI和hs-cTnT的相关性不大，证明与心脏和代谢表型的不同关联，并提供有关心力衰竭风险的补充信息。
结果：在达拉斯心脏研究参与者中测量hs-cTnI和hs-cTnT。使用线性回归评估hs-cTnI和hs-cTnT与人口统计学和表型的关联。与心力衰竭相关，动脉粥样硬化性心血管疾病，全球心血管疾病，使用Cox模型评估心血管和全因死亡率.在3276名参与者中（56%为女性，50%的黑人中位年龄43岁)，hs-cTnI和hs-cTnT之间的相关性中等(Spearmanrho=0.35)。与hs-cTnI相关但与hs-cTnT无关的变量包括高血压，较高的体重指数和总胆固醇，降低高密度脂蛋白和胆固醇的流出能力。年纪大了,男性,和糖尿病呈正相关，和吸烟呈负相关，与hs-cTnT，但不是hs-cTnI。Hs-cTnI和hs-cTnT与心力衰竭相关(风险比[HR]每SDloghs-cTnI1.53[95%CI,1.30-1.81]和HR每SDloghs-cTnT1.65[95%CI,1.40-1.95]),全球心血管疾病(HR，1.22[95%CI，1.10-1.34]和HR，1.27[95%CI，1.15-1.32])，和全因死亡率(HR，1.12[95%CI，1.01-1.25]，HR,1.17[95%CI，1.06-1.29]）。调整N末端B型利钠肽前体和替代肌钙蛋白后，两者均与心力衰竭相关(HR/SDloghs-cTnI1.32[95%CI,1.1-1.58]和HR/loghs-cTnT1.27[95%CI,1.06-1.51]).
结论：Hs-cTnI和hs-cTnT的相关性不大，证明与心脏和代谢表型的不同关联，并提供有关心力衰竭风险的补充信息。
