PDF(Pubmed)
Abstract：
Lithium may cause toxicity as it has a narrow therapeutic range. Lithium intoxication may manifest in the form of acute, acute on chronic and chronic intoxication. Neurotoxicity is a common component of chronic lithium intoxication and the symptoms include tremor, ataxia, dysarthria, extrapyramidal symptoms, hyperreflexia, seizures and status epilepticus. Although rare, catatonia could as a manifestation of lithium neurotoxicity. In this report, we present a patient with bipolar disorder presenting with catatonic symptoms secondary to lithium intoxication. We will discuss the risk factors, differential diagnosis and the treatment of catatonic symptoms. Lithium neurotoxicity may present with various clinical symptoms including catatonia, and differential diagnosis should be made well in such cases. If lithium neurotoxicity is suspected, rapid and appropriate intervention is required to prevent permanent neurological damage. Keywords: Lithium, Neurotoxicity, Catatonia.
摘要：
锂可引起毒性,因为它具有窄的治疗范围。锂中毒可能表现为急性，急性慢性和慢性中毒。神经毒性是慢性锂中毒的常见组成部分，症状包括震颤，共济失调,构音障碍,锥体外系症状,反射亢进,癫痫发作和癫痫持续状态。虽然罕见，紧张症可能是锂神经毒性的表现。在这份报告中,我们介绍了1例因锂中毒而出现紧张性症状的双相情感障碍患者.我们将讨论风险因素，紧张性症状的鉴别诊断和治疗。锂神经毒性可能存在各种临床症状，包括卡通症，在这种情况下，应该做好鉴别诊断。如果怀疑锂神经毒性，需要迅速和适当的干预，以防止永久性神经损伤。关键词:锂,神经毒性，Catatonia.
