Abstract：
Myeloid sarcoma (MS) is a solid tumor of granulocytic origin with extramedullary localization. This tumor is rare in humans and animals. The diagnostic approach is heterogeneous, and the definitive diagnosis may be difficult to achieve. Primary MS has never been described as a spontaneous neoplasm in companion dogs. Two purebred and 1 mixed-breed dogs, 6- to 11-year-old, developed round cell tumors in the mediastinum, lymph nodes (LNs) and tonsils, and LNs, respectively. Granulocytic origin and exclusion of lymphoid lineage were confirmed by flow cytometry, supported by immunohistochemistry or immunocytochemistry. Pivotal to the diagnosis were positive labeling for myeloid (CD11b, CD14) and hematopoietic precursors (CD34) markers, along with negative labeling for lymphoid markers. Blood and bone marrow infiltration were not detected at initial diagnosis, excluding acute myeloid leukemia. The behavior of these tumors was aggressive, resulting in poor clinical outcomes, even when chemotherapy was attempted.
摘要：
髓样肉瘤（MS）是粒细胞起源的实体瘤，具有髓外定位。这种肿瘤在人类和动物中很少见。诊断方法是异质的，最终的诊断可能很难实现。原发性MS从未被描述为伴侣犬的自发性肿瘤。两只纯种狗和一只混种狗，6-11岁,纵隔出现圆形细胞肿瘤，淋巴结（LNs）和扁桃体，和LNs，分别。通过流式细胞术证实粒细胞的起源和淋巴谱系的排除。由免疫组织化学或免疫细胞化学支持。诊断的关键是骨髓阳性标记(CD11b，CD14)和造血前体(CD34)标志物，以及淋巴标记的阴性标记。最初诊断时未检测到血液和骨髓浸润，不包括急性髓细胞性白血病。这些肿瘤的行为是侵袭性的，导致不良的临床结果，即使尝试化疗。
