Abstract：
While research interest in the relationship between sleep and epilepsy is growing, it primarily centres on the effects of non-rapid eye movement (NREM) sleep in favouring seizures. Nonetheless, a noteworthy aspect is the observation that, in the lives of patients with epilepsy, REM sleep represents the moment with the least epileptic activity and the lowest probability of having a seizure. Studies demonstrate a suppressive effect of phasic REM sleep on interictal epileptiform discharges, potentially offering insights into epilepsy localisation and management. Furthermore, epilepsy impacts REM sleep, with successful treatment correlating with improved REM sleep quality. Novel therapeutic strategies aim to harness REM\'s anti-epileptic effects, including pharmacological approaches targeting orexinergic systems and neuromodulation techniques promoting cortical desynchronisation. These findings underscore the intricate relationship between REM sleep and epilepsy, highlighting avenues for further research and therapeutic innovation in epilepsy management.
摘要：
虽然人们对睡眠和癫痫之间关系的研究兴趣正在增长，它主要集中在非快速眼动（NREM）睡眠对癫痫发作的影响。尽管如此，一个值得注意的方面是观察到，在癫痫患者的生活中，REM睡眠代表癫痫活动最少和癫痫发作概率最低的时刻。研究表明，阶段性REM睡眠对发作间癫痫样放电有抑制作用，可能提供有关癫痫定位和管理的见解。此外，癫痫影响REM睡眠，成功的治疗与改善的REM睡眠质量相关。新的治疗策略旨在利用REM的抗癫痫作用，包括针对食欲碱能系统的药理学方法和促进皮质去同步化的神经调节技术。这些发现强调了REM睡眠和癫痫之间的复杂关系，强调癫痫管理中进一步研究和治疗创新的途径。
