PDF(Pubmed)
Abstract：
Phentermine is an amine anorectic that acts as a sympathomimetic agent and undergoes hepatic metabolism predominantly through CYP3A4. It is commonly used as a mediation to facilitate weight loss. Side effects of phentermine can include pulmonary hypertension, valvular heart disease, palpitations, increased heart rate or blood pressure, diarrhea, and cognitive impairment. Very rarely, phentermine usage has been associated with causing ischemic colitis. The mechanism of action for ischemic colitis from phentermine is not well defined but will be discussed in this review. We present a case of a woman who used phentermine daily for weight loss and was endoscopically confirmed to have ischemic colitis after presenting with abdominal pain and bloody diarrhea.
摘要：
芬特明是一种胺类厌食症，可作为拟交感神经药，主要通过CYP3A4进行肝脏代谢。它通常用作调解，以促进减肥。芬特明的副作用可能包括肺动脉高压，心脏瓣膜病,心悸,心率或血压升高，腹泻,和认知障碍。很少,苯丁胺的使用与引起缺血性结肠炎有关。芬特明对缺血性结肠炎的作用机制尚不明确，但将在本文中进行讨论。我们介绍了一例每天使用芬特明减肥的妇女，在出现腹痛和血性腹泻后，经内镜证实患有缺血性结肠炎。
