PDF(Pubmed)
Abstract：
Modelling human diseases serves as a crucial tool to unveil underlying mechanisms and pathophysiology. Takotsubo syndrome (TS), an acute form of heart failure resembling myocardial infarction, manifests with reversible regional wall motion abnormalities (RWMA) of the ventricles. Despite its mortality and clinical similarity to myocardial infarction, TS aetiology remains elusive, with stress and catecholamines playing central roles. This review delves into current animal models of TS, aiming to assess their ability to replicate key clinical traits and identifying limitations. An in-depth evaluation of published animal models reveals a variation in the definition of TS among studies. We notice a substantial prevalence of catecholamine-induced models, particularly in rodents. While these models shed light on TS, there remains potential for refinement. Translational success in TS research hinges on models that align with human TS features and exhibit the key features, including transient RWMA. Animal models should be comprehensively evaluated regarding the various systemic changes of the applied trigger(s) for a proper interpretation. This review acts as a guide for researchers, advocating for stringent TS model standards and enhancing translational validity.
摘要：
模拟人类疾病是揭示潜在机制和病理生理学的重要工具。Takotsubo综合征（TS），类似心肌梗塞的急性心力衰竭,表现为可逆性局部室壁运动异常（RWMA）。尽管其死亡率和临床上与心肌梗死相似，TS的病因仍然难以捉摸，压力和儿茶酚胺起核心作用。这篇综述深入研究了当前的TS动物模型，旨在评估其复制关键临床特征的能力并确定局限性。对已发表的动物模型的深入评估揭示了研究中TS定义的差异。我们注意到儿茶酚胺诱导模型的大量流行，特别是在啮齿动物中。虽然这些模型揭示了TS，仍有改进的潜力。TS研究的翻译成功取决于与人类TS特征一致并展示关键特征的模型，包括瞬态RWMA。应就所应用的触发剂的各种系统变化对动物模型进行全面评估，以进行适当的解释。这篇综述为研究人员提供了指导，倡导严格的TS模型标准，提高翻译效度。
