PDF(Pubmed)
Abstract：
UNASSIGNED: Epilepsy is a common neurological disorder characterized by recurrent epilepsy episodes. As a non-pharmacological treatment, the ketogenic diet has been widely applied in treating epilepsy. However, the exact therapeutic mechanism of the ketogenic diet for epilepsy remains unclear. This study investigates the molecular mechanisms of the ketogenic diet in regulating fatty acid metabolism and activating the ADCY3-initiated cAMP signaling pathway to enhance neuronal inhibition and thereby treat epilepsy.
UNASSIGNED: Meta-analysis reveals that the ketogenic diet is superior to the conventional diet in treating epilepsy. Animal experiments demonstrate that the ketogenic diet is more effective than the conventional diet in treating epilepsy, with the best results achieved using the classic ketogenic diet. Transcriptome sequencing analysis identifies six essential genes, among which ADCY3 shows increased expression in the ketogenic diet. In vivo experiments confirm that the activation of the cAMP-PKA signaling pathway by ADCY3 enhances neuronal inhibition and improves epilepsy control.
UNASSIGNED: Clinical observations indicate that the ketogenic diet improves patient epilepsy episodes by regulating the ADCY3-initiated cAMP signaling pathway.
UNASSIGNED: Meta-analysis reveals that the ketogenic diet is superior to the conventional diet in treating epilepsy. Animal experiments demonstrate that the ketogenic diet is more effective than the conventional diet in treating epilepsy, with the best results achieved using the classic ketogenic diet. Transcriptome sequencing analysis identifies six essential genes, among which ADCY3 shows increased expression in the ketogenic diet. In vivo experiments confirm that the activation of the cAMP-PKA signaling pathway by ADCY3 enhances neuronal inhibition and improves epilepsy control.
UNASSIGNED: Clinical observations indicate that the ketogenic diet improves patient epilepsy episodes by regulating the ADCY3-initiated cAMP signaling pathway.
摘要：
癫痫是一种常见的神经系统疾病，以反复发作的癫痫发作为特征。作为一种非药物治疗，生酮饮食已广泛应用于癫痫的治疗。然而,生酮饮食治疗癫痫的确切机制尚不清楚.本研究探讨生酮饮食在调节脂肪酸代谢和激活ADCY3启动的cAMP信号通路以增强神经元抑制从而治疗癫痫的分子机制。
■Meta分析显示，生酮饮食在治疗癫痫方面优于常规饮食。动物实验表明，生酮饮食比常规饮食治疗癫痫更有效，使用经典生酮饮食取得的最佳效果。转录组测序分析确定了六个必需基因，其中ADCY3在生酮饮食中显示表达增加。体内实验证实，ADCY3对cAMP-PKA信号通路的激活增强了神经元的抑制作用并改善了癫痫的控制。
■临床观察表明，生酮饮食通过调节ADCY3启动的cAMP信号通路改善患者癫痫发作。
■Meta分析显示，生酮饮食在治疗癫痫方面优于常规饮食。动物实验表明，生酮饮食比常规饮食治疗癫痫更有效，使用经典生酮饮食取得的最佳效果。转录组测序分析确定了六个必需基因，其中ADCY3在生酮饮食中显示表达增加。体内实验证实，ADCY3对cAMP-PKA信号通路的激活增强了神经元的抑制作用并改善了癫痫的控制。
■临床观察表明，生酮饮食通过调节ADCY3启动的cAMP信号通路改善患者癫痫发作。
