PDF(Pubmed)
Abstract：
Epithelial-myoepithelial carcinoma (EMC) is a rare tumor, characterized by two different cell populations and both demonstrate a malignant nature microscopically. It constitutes less than 2% of all salivary gland malignancies. The World Health Organization (WHO) has classified this disease as a separate pathological category. The diagnosis of this tumor is arrived by biopsy. It shows slow growth and is small in size; it appears in ulcerative form of mucosa in some cases. Gland cells consist of two layers of outer myoepithelium cells and inner epithelial cells. Vimentin staining is positive. It shows calponin, muscle-specific actin, S100, smooth muscle actin, p63, and smooth muscle myosin heavy chain I. Examining different sets of data reveals that tumors exhibiting a solid growth pattern, nuclear atypia, DNA aneuploidy, and increased proliferative activity typically display a more aggressive nature, accompanied by a heightened likelihood of local recurrences and metastases. The clinical and radiological observations frequently resemble those of a benign tumor. Due to the uncommon nature of EMC, there is currently no established standard treatment protocol. It is considered a low-grade tumor where good resection holds better results. Individuals displaying histopathological indicators of aggressive disease should be evaluated for potential adjuvant radiotherapy. We present a case of a patient who had recurrence twice in a period of seven years despite surgical management, chemotherapy, and radiotherapy.
摘要：
上皮-肌上皮癌（EMC）是一种罕见的肿瘤，以两种不同的细胞群体为特征，并且在显微镜下都显示出恶性性质。它占所有唾液腺恶性肿瘤的不到2％。世界卫生组织（WHO）已将这种疾病归类为单独的病理类别。这种肿瘤的诊断是通过活检得出的。它显示出缓慢的生长并且体积较小；在某些情况下它以粘膜的溃疡形式出现。腺体细胞由两层外肌上皮细胞和内上皮细胞组成。波形蛋白染色为阳性。它显示了Calponin,肌肉特异性肌动蛋白，S100，平滑肌肌动蛋白，P63和平滑肌肌球蛋白重链I检查不同组的数据显示，肿瘤表现出固体生长模式，核非典型性,DNA非整倍性,和增加的增殖活性通常表现出更积极的性质，伴随着局部复发和转移的可能性增加。临床和放射学观察结果通常类似于良性肿瘤。由于EMC的特殊性，目前尚无既定的标准治疗方案.它被认为是低度肿瘤，良好的切除效果更好。应评估显示侵袭性疾病的组织病理学指标的个体是否有潜在的辅助放疗。我们介绍了一例患者，尽管进行了手术治疗，但在7年内复发了两次，化疗,和放射治疗。
