PDF(Pubmed)
Abstract：
Skeletal muscle regeneration relies on the intricate interplay of various cell populations within the muscle niche-an environment crucial for regulating the behavior of muscle stem cells (MuSCs) and ensuring postnatal tissue maintenance and regeneration. This review delves into the dynamic interactions among key players of this process, including MuSCs, macrophages (MPs), fibro-adipogenic progenitors (FAPs), endothelial cells (ECs), and pericytes (PCs), each assuming pivotal roles in orchestrating homeostasis and regeneration. Dysfunctions in these interactions can lead not only to pathological conditions but also exacerbate muscular dystrophies. The exploration of cellular and molecular crosstalk among these populations in both physiological and dystrophic conditions provides insights into the multifaceted communication networks governing muscle regeneration. Furthermore, this review discusses emerging strategies to modulate the muscle-regenerating niche, presenting a comprehensive overview of current understanding and innovative approaches.
摘要：
骨骼肌再生依赖于肌肉生态位内的各种细胞群的复杂相互作用,肌肉生态位是调节肌肉干细胞(MuSC)的行为和确保出生后组织维持和再生的关键环境。这篇综述深入研究了这一过程的关键参与者之间的动态互动，包括MuSC,巨噬细胞（MPs），纤维脂肪原祖细胞（FAP），内皮细胞（ECs），和周细胞(PC)，每个人都在协调体内平衡和再生方面发挥着关键作用。这些相互作用中的功能障碍不仅会导致病理状况，还会加剧肌营养不良。在生理和营养不良条件下，对这些人群之间的细胞和分子串扰的探索提供了对控制肌肉再生的多方面通信网络的见解。此外，这篇综述讨论了调节肌肉再生生态位的新兴策略，全面概述当前的理解和创新方法。
