PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the primary causes and clinical characteristics of cystic encephalomalacia (CE) in children.
UNASSIGNED: The clinical data of 50 children who were admitted to our hospital due to CE between January 2008 and December 2020 were retrospectively reviewed. Their primary causes, clinical manifestations and cranial magnetic resonance imaging features were analyzed.
UNASSIGNED: Among all patients, 5 had prematurity, 19 had hypoxic-ischemic encephalopathy (HIE), 13 had intracranial infection, 14 had traumatic brain injury and hemorrhage, 4 had cerebral infarction, 2 had congenital genetic diseases, and 1 had hypoglycemia. The average time from primary disease onset to CE diagnosis was 70.1 ± 61.0 days. The clinical manifestations included speech or motor developmental delay (n = 33), epilepsy (n = 31), dystonia (n = 27), limb paralysis (n = 16), and visual or auditory impairment (n = 5). Patients with HIE as the primary cause of CE had a significantly higher occurrence of dystonia, while a significantly higher incidence of paralysis was observed in those with cerebral infarction as the primary cause.
UNASSIGNED: CE in children is mainly caused by HIE, intracranial infection, and cerebral hemorrhage. The major clinical manifestations included speech or motor developmental delay, epilepsy, and dystonia. Magnetic resonance imaging is an important tool for the diagnosis of CE.
UNASSIGNED: The clinical data of 50 children who were admitted to our hospital due to CE between January 2008 and December 2020 were retrospectively reviewed. Their primary causes, clinical manifestations and cranial magnetic resonance imaging features were analyzed.
UNASSIGNED: Among all patients, 5 had prematurity, 19 had hypoxic-ischemic encephalopathy (HIE), 13 had intracranial infection, 14 had traumatic brain injury and hemorrhage, 4 had cerebral infarction, 2 had congenital genetic diseases, and 1 had hypoglycemia. The average time from primary disease onset to CE diagnosis was 70.1 ± 61.0 days. The clinical manifestations included speech or motor developmental delay (n = 33), epilepsy (n = 31), dystonia (n = 27), limb paralysis (n = 16), and visual or auditory impairment (n = 5). Patients with HIE as the primary cause of CE had a significantly higher occurrence of dystonia, while a significantly higher incidence of paralysis was observed in those with cerebral infarction as the primary cause.
UNASSIGNED: CE in children is mainly caused by HIE, intracranial infection, and cerebral hemorrhage. The major clinical manifestations included speech or motor developmental delay, epilepsy, and dystonia. Magnetic resonance imaging is an important tool for the diagnosis of CE.
摘要：
■探讨儿童囊性脑软化症（CE）的主要病因和临床特征。
■回顾性分析了2008年1月至2020年12月间因CE入院的50名儿童的临床资料。他们的主要原因，分析临床表现和头颅磁共振成像特点。
■在所有患者中，5有早产，19人患有缺氧缺血性脑病（HIE），13人颅内感染,14人患有创伤性脑损伤和出血，4有脑梗塞，2人患有先天性遗传病，1例低血糖。从原发疾病发作到CE诊断的平均时间为70.1±61.0天。临床表现包括言语或运动发育迟缓（n=33），癫痫（n=31），肌张力障碍（n=27），肢体瘫痪（n=16），和视觉或听觉障碍（n=5）。以HIE为主要病因的CE患者的肌张力障碍发生率明显增高，而在以脑梗塞为主要原因的患者中，瘫痪的发生率明显更高。
■儿童CE主要是由HIE引起的，颅内感染,还有脑出血.主要临床表现包括言语或运动发育迟缓，癫痫,和肌张力障碍.磁共振成像是诊断CE的重要工具。
■回顾性分析了2008年1月至2020年12月间因CE入院的50名儿童的临床资料。他们的主要原因，分析临床表现和头颅磁共振成像特点。
■在所有患者中，5有早产，19人患有缺氧缺血性脑病（HIE），13人颅内感染,14人患有创伤性脑损伤和出血，4有脑梗塞，2人患有先天性遗传病，1例低血糖。从原发疾病发作到CE诊断的平均时间为70.1±61.0天。临床表现包括言语或运动发育迟缓（n=33），癫痫（n=31），肌张力障碍（n=27），肢体瘫痪（n=16），和视觉或听觉障碍（n=5）。以HIE为主要病因的CE患者的肌张力障碍发生率明显增高，而在以脑梗塞为主要原因的患者中，瘫痪的发生率明显更高。
■儿童CE主要是由HIE引起的，颅内感染,还有脑出血.主要临床表现包括言语或运动发育迟缓，癫痫,和肌张力障碍.磁共振成像是诊断CE的重要工具。
