PDF(Pubmed)
Abstract：
UNASSIGNED: We present the case of a 65-year-old patient who was treated with high-dose benzylpenicillin for severe invasive pneumococcal pneumonia, complicated by acute renal failure managed with continuous venovenous hemofiltration. After cessation of continuous venovenous hemofiltration, the patient experienced multiple tonic-clonic seizures. Therapeutic drug monitoring revealed high total serum concentrations of benzylpenicillin, identifying it as the likely cause of the neurotoxicity. This case study presents the first documented total serum benzylpenicillin concentration associated with neurotoxicity.
摘要：
■我们介绍了一个65岁的患者，他接受了大剂量的苄青霉素治疗严重的侵袭性肺炎球菌肺炎，并发急性肾功能衰竭，采用连续静脉-静脉血液滤过治疗。连续静脉-静脉血液滤过停止后,患者经历了多次强直阵挛性癫痫发作。治疗药物监测显示苄青霉素的血清总浓度很高，确定它是神经毒性的可能原因。此案例研究提供了第一个记录的与神经毒性相关的血清苄青霉素总浓度。
