关键词: Asphyxia Autopsy CMV pneumonia Intermittent pulmonary hemorrhage Interstitial pneumonia Neonatal

Mesh : Humans Cytomegalovirus Infections / complications diagnosis Infant, Newborn Male Fatal Outcome Hemorrhage / etiology Cytomegalovirus Lung / pathology diagnostic imaging virology Pneumonia, Viral / complications diagnosis virology Autopsy Lung Diseases / virology etiology

来  源:   DOI:10.1186/s12985-024-02399-7   PDF(Pubmed)

Abstract:
Neonatal pulmonary hemorrhage is a late manifestation of various diseases. Premature delivery and low body weight are frequently observed as high-risk factors, characterized by acute onset, rapid progression, and high mortality rates. Pulmonary hemorrhage caused by cytomegalovirus infection in newborns with normal immune function is a rare occurrence. This case report focuses on a term neonate with normal birth weight who presented solely with nasal obstruction shortly after birth. However, 4 days after birth, the newborn experienced a sudden onset of blood gushing from both the mouth and nasal cavity. The patient was diagnosed with gastrointestinal bleeding, neonatal pneumonia and neonatal lung consolidation. And he was discharged after ten days of symptomatic treatment. However, upon returning home, the patient experienced a sudden onset of bleeding from the mouth and nose, leading to his untimely demise. Subsequent autopsy revealed the presence of pulmonary hemorrhage in newborn, which presented as interstitial pneumonia. The cause of pulmonary hemorrhage is cytomegalovirus infection. This case emphasizes the importance of pediatricians enhancing their skills in differentiating pulmonary hemorrhage, especially from cytomegalovirus pneumonia.
摘要:
新生儿肺出血是多种疾病的晚期表现。早产和低体重常被视为高危因素,以急性发作为特征,快速发展,和高死亡率。巨细胞病毒感染引起的肺出血在免疫功能正常的新生儿中是罕见的。该病例报告的重点是出生体重正常的足月新生儿,其出生后不久仅出现鼻塞。然而,出生后4天,新生儿突然从口腔和鼻腔涌出血液。病人被诊断为消化道出血,新生儿肺炎和新生儿肺实变。对症治疗十天后出院。然而,回家后,患者突然出现口鼻出血,导致他不合时宜的死亡。随后的尸检显示新生儿存在肺出血,表现为间质性肺炎。肺出血的原因是巨细胞病毒感染。本病例强调儿科医生提高鉴别肺出血的技能的重要性,尤其是巨细胞病毒肺炎.
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