PDF(Pubmed)
Abstract：
People who inject drugs are frequently colonized with Staphylococcus aureus and have an increased risk for skin and soft tissue infections. This longitudinal study aims to describe S. aureus carriage in this group and the risk for infections during a 1-year follow-up. We included 61 participants from the Malmö Needle Exchange Program. Mapping of S. aureus carriage was conducted by screening cultures every third month and S. aureus growth was semi-quantified. Data regarding infections and living conditions were collected from structured interviews. Statistics included univariate analysis with the Fischer\'s exact test, univariate logistic regression and multivariate logistic regression. S. aureus carriage was detected in 46-63% of participants, and 75% reported one or more infections during the study period. Self-reported infections were associated with carriage in perineum (OR 5.08 [95% CI 1.45-17.73]), in skin lesions (OR 1.48 [95% CI 1.21-1.81]), and unstable housing situation (OR 12.83 [95% CI 1.56-105.81]). Thus, people who inject drugs are frequent carriers of S. aureus and report a surprisingly high prevalence of skin and soft tissue infections. Homeless people and those with skin carriage seem to be at highest risk. Effective clinical interventions are needed, aiming at preventing infections in this vulnerable group.
摘要：
注射药物的人经常被金黄色葡萄球菌定植，皮肤和软组织感染的风险增加。这项纵向研究旨在描述该组中金黄色葡萄球菌的携带以及1年随访期间感染的风险。我们包括来自马尔默针头交换计划的61名参与者。通过每三个月筛选培养物进行金黄色葡萄球菌携带的定位,并对金黄色葡萄球菌生长进行半定量。有关感染和生活条件的数据是从结构化访谈中收集的。统计包括单变量分析和费舍尔精确检验，单变量逻辑回归和多变量逻辑回归。在46-63%的参与者中检测到金黄色葡萄球菌的携带，75%的患者在研究期间报告了一种或多种感染。自我报告的感染与会阴携带相关（OR5.08[95％CI1.45-17.73]），在皮肤病变中（OR1.48[95%CI1.21-1.81]），住房状况不稳定(OR12.83[95%CI1.56-105.81])。因此，注射药物的人是金黄色葡萄球菌的频繁携带者，并且报告了皮肤和软组织感染的高患病率。无家可归的人和有皮肤运输的人似乎面临最高的风险。需要有效的临床干预措施，旨在防止这一弱势群体的感染。
