PDF(Pubmed)
Abstract：
While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-L-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.
摘要：
虽然挥发性有机化合物（VOCs）损害各种器官，它们对听力损失（HL）的影响尚未得到广泛研究。我们旨在确定VOCs与HL或高频听力损失（HFHL）之间的关联。我们提取了年龄数据，性别,纯音测听法,高血压,职业噪声暴露,和肌酐校正尿VOC代谢物浓度从第八届韩国国家健康和营养调查。在VOC代谢物中，N-乙酰基-S-(苄基)-L-半胱氨酸(BMA,P=0.004),N-乙酰基-S-（苯基）-L-半胱氨酸（SPMA，P=0.027),和N-乙酰基-S-（3,4-二羟基丁基）-L-半胱氨酸（DHBMA，P<0.001)显示与HL相关。此外,HFHL与BMA显著相关(P=0.005),3-和4-甲基马尿酸（3，4MHA，P=0.049),扁桃酸（MA，P=0.015),SPMA（P<0.001），N-乙酰基-S-（3-羟丙基）-L-半胱氨酸（3-HPMA，P<0.001)，和DHBMA（P<0.001）。在控制其他因素后，DHBMA与HL（P=0.021）和HFHL（P=0.014）相关，并与平均听力水平（β=0.054，P=0.024）和高频听力水平（β=0.045，P=0.037）呈线性关系。由于1,3-丁二烯可以充当耳毒性材料，对接触1,3-丁二烯的工人进行早期筛查,并减少日常生活中1,3-丁二烯的接触,可能有助于预防进一步的HL.
