Abstract：
OBJECTIVE: To investigate a possible link between acute Epstein-Barr virus infection and Lemierre syndrome, a rare yet life-threatening infection.
METHODS: A systematic review was conducted adhering to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnosis criteria for Lemierre syndrome were established, and data extraction encompassed demographic data, clinical, and laboratory information.
RESULTS: Out of 985 initially identified papers, 132 articles were selected for the final analysis. They reported on 151 cases of Lemierre syndrome (76 female and 75 male patients with a median of 18 years) alongside interpretable results for Epstein-Barr virus serology. Among these, 38 cases (25%) tested positive for acute Epstein-Barr virus serology. There were no differences in terms of age, sex, or Fusobacterium presence between the serologically positive and negative groups. Conversely, instances of cervical thrombophlebitis and pulmonary complications were significantly higher (P = 0.0001) among those testing negative. The disease course was lethal in one case for each of the two groups.
CONCLUSIONS: This analysis provides evidence of an association between acute Epstein-Barr virus infection and Lemierre syndrome. Raising awareness of this link within the medical community is desirable.
METHODS: A systematic review was conducted adhering to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnosis criteria for Lemierre syndrome were established, and data extraction encompassed demographic data, clinical, and laboratory information.
RESULTS: Out of 985 initially identified papers, 132 articles were selected for the final analysis. They reported on 151 cases of Lemierre syndrome (76 female and 75 male patients with a median of 18 years) alongside interpretable results for Epstein-Barr virus serology. Among these, 38 cases (25%) tested positive for acute Epstein-Barr virus serology. There were no differences in terms of age, sex, or Fusobacterium presence between the serologically positive and negative groups. Conversely, instances of cervical thrombophlebitis and pulmonary complications were significantly higher (P = 0.0001) among those testing negative. The disease course was lethal in one case for each of the two groups.
CONCLUSIONS: This analysis provides evidence of an association between acute Epstein-Barr virus infection and Lemierre syndrome. Raising awareness of this link within the medical community is desirable.
摘要：
目的：探讨急性EB病毒感染与Lemierre综合征之间的可能联系。一种罕见但危及生命的感染.
方法：根据2020年系统评价和荟萃分析指南首选报告项目进行系统评价。建立了Lemierre综合征的诊断标准，数据提取包括人口统计数据，临床,实验室信息。
结果：在985篇最初确定的论文中，最终选择132篇文章进行分析。他们报告了151例Lemierre综合征（76名女性和75名男性患者，中位年龄为18岁）以及可解释的Epstein-Barr病毒血清学结果。其中,急性EB病毒血清学检测阳性38例(25%)。在年龄方面没有差异，性别,或在血清学阳性和阴性组之间存在梭杆菌。相反，在检测阴性者中,宫颈血栓性静脉炎和肺部并发症的发生率明显较高(P=0.0001).对于两组中的每一组，病程在一个病例中是致命的。
结论：本分析提供了急性EB病毒感染与Lemierre综合征之间关联的证据。提高医学界对这种联系的认识是可取的。
方法：根据2020年系统评价和荟萃分析指南首选报告项目进行系统评价。建立了Lemierre综合征的诊断标准，数据提取包括人口统计数据，临床,实验室信息。
结果：在985篇最初确定的论文中，最终选择132篇文章进行分析。他们报告了151例Lemierre综合征（76名女性和75名男性患者，中位年龄为18岁）以及可解释的Epstein-Barr病毒血清学结果。其中,急性EB病毒血清学检测阳性38例(25%)。在年龄方面没有差异，性别,或在血清学阳性和阴性组之间存在梭杆菌。相反，在检测阴性者中,宫颈血栓性静脉炎和肺部并发症的发生率明显较高(P=0.0001).对于两组中的每一组，病程在一个病例中是致命的。
结论：本分析提供了急性EB病毒感染与Lemierre综合征之间关联的证据。提高医学界对这种联系的认识是可取的。
