关键词: Intensive care Liver disease Medical management Pancreatitis

Mesh : Humans Male Prednisolone / therapeutic use Glycoproteins Pancreatitis / chemically induced drug therapy Adult Trypsin Inhibitors / therapeutic use Arthritis, Rheumatoid / drug therapy Glucocorticoids / therapeutic use adverse effects

来  源:   DOI:10.1136/bcr-2024-260019

Abstract:
Steroid-induced acute pancreatitis is a rare form of pancreatitis that requires intensive care and has a high morbidity and mortality rate as there is no specific treatment. Management of steroid-induced pancreatitis is generally non-specific and supportive. Here, we are presenting a man in his 40s presented with epigastric pain, fever and vomiting. The patient was diagnosed case of rheumatoid arthritis, for which he was receiving regular 5 mg oral prednisolone therapy. Based on history, and clinical, biochemical and radiological imaging a diagnosis of steroid-induced pancreatitis was made, which was successfully managed with the help of ulinastatin and other supportive treatments. A serine protease inhibitor like ulinastatin may be used early in the clinical management of steroid-induced pancreatitis.
摘要:
类固醇诱导的急性胰腺炎是一种罕见的胰腺炎形式,需要重症监护,并且由于没有特殊的治疗方法而具有很高的发病率和死亡率。类固醇诱导的胰腺炎的管理通常是非特异性和支持性的。这里,我们展示了一个40多岁的男人,他有上腹痛,发烧和呕吐。患者被诊断为类风湿性关节炎,他正在接受常规的5mg口服泼尼松龙治疗。基于历史,临床,生化和放射影像学诊断为类固醇诱导的胰腺炎,在乌司他丁和其他支持治疗的帮助下成功管理。像乌司他丁这样的丝氨酸蛋白酶抑制剂可以早期用于类固醇诱导的胰腺炎的临床治疗。
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