Abstract：
OBJECTIVE: To increase awareness and improve perioperative care of patients with cleft palate (CP) and coexisting cardiopulmonary anomalies.
METHODS: Retrospective cohort.
METHODS: Multi-center.
METHODS: Patients who underwent surgical repair of CP between 2012-2020 identified in the American College of Surgeons National Surgical Quality Improvement Program Pediatric Data File. Chi-squared analysis and Student\'s t-test were implemented to make associations between congenital heart disease (CHD) and congenital pulmonary disease (CPD) and postoperative complications. Multiple logistic regression was performed to identify associations between CP and CHD/CPD while controlling for age, gender, and ASA class. C2 values were used to assess the logistic regressions, with a significance level of 0.05 indicating statistical significance.
METHODS: Length of stay (LOS), perioperative complications (readmission, reoperation, reintubation, wound dehiscence, cerebrovascular accidents, and mortality).
RESULTS: 9 96 181 patients were identified in the database, 17 786 of whom were determined to have CP, of whom 16.0% had congenital heart defects (CHD) and 13.2% had congenital pulmonary defects (CPD). Patients with CHD and CPD were at a significantly greater risk of increased LOS and all but one operative complication rate (wound dehiscence) relative to patients with CP without a history of CHD and CPD.
CONCLUSIONS: This study suggests that congenital cardiopulmonary disease is associated with increased adverse outcomes in the setting of CP repair. Thus, heightened clinical suspicion for coexisting congenital anomalies in the presence of CP should prompt referring providers to perform a comprehensive and multidisciplinary evaluation to ensure cardiopulmonary optimization prior to surgical intervention.
METHODS: Retrospective cohort.
METHODS: Multi-center.
METHODS: Patients who underwent surgical repair of CP between 2012-2020 identified in the American College of Surgeons National Surgical Quality Improvement Program Pediatric Data File. Chi-squared analysis and Student\'s t-test were implemented to make associations between congenital heart disease (CHD) and congenital pulmonary disease (CPD) and postoperative complications. Multiple logistic regression was performed to identify associations between CP and CHD/CPD while controlling for age, gender, and ASA class. C2 values were used to assess the logistic regressions, with a significance level of 0.05 indicating statistical significance.
METHODS: Length of stay (LOS), perioperative complications (readmission, reoperation, reintubation, wound dehiscence, cerebrovascular accidents, and mortality).
RESULTS: 9 96 181 patients were identified in the database, 17 786 of whom were determined to have CP, of whom 16.0% had congenital heart defects (CHD) and 13.2% had congenital pulmonary defects (CPD). Patients with CHD and CPD were at a significantly greater risk of increased LOS and all but one operative complication rate (wound dehiscence) relative to patients with CP without a history of CHD and CPD.
CONCLUSIONS: This study suggests that congenital cardiopulmonary disease is associated with increased adverse outcomes in the setting of CP repair. Thus, heightened clinical suspicion for coexisting congenital anomalies in the presence of CP should prompt referring providers to perform a comprehensive and multidisciplinary evaluation to ensure cardiopulmonary optimization prior to surgical intervention.
摘要：
目的：提高对腭裂(CP)合并心肺功能异常患者的认识，改善围手术期护理。
方法：回顾性队列。
方法：多中心。
方法：在美国外科医师学会国家外科质量改善计划儿科数据文件中确定的2012-2020年间接受CP手术修复的患者。采用卡方分析和学生t检验对先天性心脏病（CHD）和先天性肺病（CPD）与术后并发症进行关联。在控制年龄的同时，进行多元逻辑回归以确定CP和CHD/CPD之间的关联。性别,和ASA类。C2值用于评估逻辑回归，0.05的显著性水平表示有统计学意义。
方法：停留时间（LOS），围手术期并发症（再入院，再操作,再插管,伤口裂开,脑血管意外,和死亡率）。
结果：9在数据库中确定了96181名患者，其中17786人被确定患有CP，其中16.0％患有先天性心脏缺陷（CHD），13.2％患有先天性肺缺陷（CPD）。与没有CHD和CPD病史的CP患者相比，CHD和CPD患者的LOS增加和手术并发症发生率（伤口裂开）的风险明显更高。
结论：这项研究表明，先天性心肺疾病与CP修复的不良结局增加有关。因此，临床上对CP同时存在的先天性异常的怀疑增加,应促使转诊提供者进行全面的多学科评估,以确保在手术干预前优化心肺功能.
方法：回顾性队列。
方法：多中心。
方法：在美国外科医师学会国家外科质量改善计划儿科数据文件中确定的2012-2020年间接受CP手术修复的患者。采用卡方分析和学生t检验对先天性心脏病（CHD）和先天性肺病（CPD）与术后并发症进行关联。在控制年龄的同时，进行多元逻辑回归以确定CP和CHD/CPD之间的关联。性别,和ASA类。C2值用于评估逻辑回归，0.05的显著性水平表示有统计学意义。
方法：停留时间（LOS），围手术期并发症（再入院，再操作,再插管,伤口裂开,脑血管意外,和死亡率）。
结果：9在数据库中确定了96181名患者，其中17786人被确定患有CP，其中16.0％患有先天性心脏缺陷（CHD），13.2％患有先天性肺缺陷（CPD）。与没有CHD和CPD病史的CP患者相比，CHD和CPD患者的LOS增加和手术并发症发生率（伤口裂开）的风险明显更高。
结论：这项研究表明，先天性心肺疾病与CP修复的不良结局增加有关。因此，临床上对CP同时存在的先天性异常的怀疑增加,应促使转诊提供者进行全面的多学科评估,以确保在手术干预前优化心肺功能.
