Abstract：
Hyaluronic acid (HA), an endogenous polysaccharide comprising alternating D-glucuronic acid and N-acetylglucosamine units, is renowned for its high hydrophilicity, biocompatibility, and biodegradability. These attributes have rendered HA invaluable across medical and drug delivery fields. HA can be altered through physical, chemical, or enzymatic methods to improve the properties of the modified substances. In this work, we synthesized a derivative via the esterification of HA with poly(glyceryl)10-stearate (PG10-C18), designated as HA-PG10-C18. This novel derivative was employed to fabricate a nano co-delivery system (HA-PG10-C18@Res-NE) for fish oil and resveratrol (Res), aiming to enhance their stability and bioaccessibility. An exhaustive investigation of HA-PG10-C18@Res-NE revealed that the HA-modified system displayed superior physicochemical stability, notably in withstanding oxidation and neutralizing free radicals. Moreover, in vitro simulated digestion underscored the system\'s enhanced bioaccessibility of Res and more efficient release of free fatty acids. These outcomes underscore the strategic advantage of HA in modifying PG10-C18 for nanoemulsion formulation. Consequently, HA-PG10-C18 stands as a promising emulsifier for encapsulating lipophilic bioactives in functional foods, nutraceuticals, and pharmaceuticals.
摘要：
透明质酸(HA),包含交替的D-葡糖醛酸和N-乙酰葡糖胺单元的内源性多糖，以其高亲水性而闻名，生物相容性，和生物降解性。这些属性使得HA在医疗和药物递送领域具有无价价值。HA可以通过身体改变，化学,或酶的方法来改善改性物质的性质。在这项工作中,我们通过HA与聚（甘油）10-硬脂酸酯（PG10-C18）的酯化合成了衍生物，指定为HA-PG10-C18。该新型衍生物用于制造鱼油和白藜芦醇（Res）的纳米共递送系统（HA-PG10-C18@Res-NE），旨在增强它们的稳定性和生物可及性。对HA-PG10-C18@Res-NE的详尽研究表明，HA修饰的系统显示出优异的物理化学稳定性，特别是在承受氧化和中和自由基。此外，体外模拟消化强调了该系统增强的Res生物可及性和更有效的游离脂肪酸释放。这些结果强调了HA在修饰纳米乳液制剂的PG10-C18中的战略优势。因此,HA-PG10-C18是一种有前途的乳化剂，用于将亲脂性生物活性物质封装在功能性食品中，营养食品，和药物。
