由突变的 DNMT3A 驱动的克隆造血促进炎性骨丢失。
关键词: DNMT3A T cells arthritis bone marrow clonal hematopoiesis of indeterminate potential hematopoietic stem and progenitor cells inflammation neutrophils osteoclastogenesis periodontitis
Mesh : DNA Methyltransferase 3A Animals DNA (Cytosine-5-)-Methyltransferases / metabolism genetics Mice Clonal Hematopoiesis / genetics Humans Periodontitis / genetics pathology Mutation Male Female Inflammation / genetics pathology Osteoclasts / metabolism Mice, Inbred C57BL Adult Interleukin-17 / metabolism genetics T-Lymphocytes, Regulatory / immunology metabolism Hematopoiesis / genetics Osteogenesis / genetics Hematopoietic Stem Cells / metabolism Bone Resorption / genetics pathology Middle Aged
来 源:
DOI:10.1016/j.cell.2024.05.003
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