Abstract：
OBJECTIVE: To evaluate if it possible to improve ovarian reserve parameters and oocyte retrieval in poor responders who undergo intraovarian injection of platelet-rich plasma (PRP).
METHODS: Prospective cohort study. We included 148 poor responders who underwent PRP injection between October 2021 and December 2022 in our institution, comparing pre and post PRP ovarian function. In addition, the IVF outcomes of a subgroup of patients was studied after the intervention in contrast with the previous treatment.
RESULTS: An improvement in ovarian reserve was observed in relation to previous values: FSH (13.57 vs. 11.32, p=0.11), AMH (0.39 vs. 0.48, p=0.06), antral follicle count (3.98 vs. 5.75, p<0.001); as well as a higher number of oocytes retrieved (2.63 vs. 3.65, p=0.01) and produced embryos (1.64 vs. 2.22, p=0.03); without a great impact on pregnancy rates.
CONCLUSIONS: Although experimental, intraovarian PRP could restore ovarian function and be postulated as an alternative to oocyte donation in patients with low ovarian reserve who do not accept this treatment. There is a lack of randomized controlled trials to support these findings.
METHODS: Prospective cohort study. We included 148 poor responders who underwent PRP injection between October 2021 and December 2022 in our institution, comparing pre and post PRP ovarian function. In addition, the IVF outcomes of a subgroup of patients was studied after the intervention in contrast with the previous treatment.
RESULTS: An improvement in ovarian reserve was observed in relation to previous values: FSH (13.57 vs. 11.32, p=0.11), AMH (0.39 vs. 0.48, p=0.06), antral follicle count (3.98 vs. 5.75, p<0.001); as well as a higher number of oocytes retrieved (2.63 vs. 3.65, p=0.01) and produced embryos (1.64 vs. 2.22, p=0.03); without a great impact on pregnancy rates.
CONCLUSIONS: Although experimental, intraovarian PRP could restore ovarian function and be postulated as an alternative to oocyte donation in patients with low ovarian reserve who do not accept this treatment. There is a lack of randomized controlled trials to support these findings.
摘要：
目的：评估是否可以改善卵巢内注射富血小板血浆（PRP）的反应不良者的卵巢储备参数和卵母细胞回收。
方法：前瞻性队列研究。我们包括148名在2021年10月至2022年12月期间接受PRP注射的不良反应者，比较PRP前后卵巢功能。此外,与之前的治疗相比,在干预后研究了一组患者的IVF结局.
结果：观察到卵巢储备与以前的值有关：FSH（13.57vs.11.32，p=0.11)，AMH（0.39vs.0.48，p=0.06），窦卵泡计数（3.98vs.5.75，p<0.001）；以及更多的卵母细胞回收（2.63vs.3.65，p=0.01）和产生的胚胎（1.64vs.2.22，p=0.03）；对怀孕率没有很大影响。
结论：虽然是实验性的，卵巢内PRP可恢复卵巢功能,对于不接受该治疗的低卵巢储备患者,可替代卵母细胞捐献.缺乏支持这些发现的随机对照试验。
方法：前瞻性队列研究。我们包括148名在2021年10月至2022年12月期间接受PRP注射的不良反应者，比较PRP前后卵巢功能。此外,与之前的治疗相比,在干预后研究了一组患者的IVF结局.
结果：观察到卵巢储备与以前的值有关：FSH（13.57vs.11.32，p=0.11)，AMH（0.39vs.0.48，p=0.06），窦卵泡计数（3.98vs.5.75，p<0.001）；以及更多的卵母细胞回收（2.63vs.3.65，p=0.01）和产生的胚胎（1.64vs.2.22，p=0.03）；对怀孕率没有很大影响。
结论：虽然是实验性的，卵巢内PRP可恢复卵巢功能,对于不接受该治疗的低卵巢储备患者,可替代卵母细胞捐献.缺乏支持这些发现的随机对照试验。
