Abstract：
Spontaneous reversion from mild cognitive impairment (MCI) to normal cognition (NC) is little known. Based on the data of the Genetics of Personality Consortium and MCI participants from Alzheimer\'s Disease Neuroimaging Initiative, the authors investigate the effect of polygenic scores (PGS) for personality traits on the reversion of MCI to NC and its underlying neurobiology. PGS analysis reveals that PGS for conscientiousness (PGS-C) is a protective factor that supports the reversion from MCI to NC. Gene ontology enrichment analysis and tissue-specific enrichment analysis indicate that the protective effect of PGS-C may be attributed to affecting the glutamatergic synapses of subcortical structures, such as hippocampus, amygdala, nucleus accumbens, and caudate nucleus. The structural covariance network (SCN) analysis suggests that the left whole hippocampus and its subfields, and the left whole amygdala and its subnuclei show significantly stronger covariance with several high-cognition relevant brain regions in the MCI reverters compared to the stable MCI participants, which may help illustrate the underlying neural mechanism of the protective effect of PGS-C.
摘要：
从轻度认知障碍（MCI）到正常认知（NC）的自发逆转鲜为人知。基于遗传学的人格联盟和MCI参与者从阿尔茨海默病神经影像学倡议的数据，作者研究了人格特质的多基因评分（PGS）对MCI向NC的逆转及其潜在神经生物学的影响。PGS分析表明，出于责任心的PGS（PGS-C）是一个保护因素，支持从MCI到NC的回归。基因本体论富集分析和组织特异性富集分析表明，PGS-C的保护作用可能归因于影响皮质下结构的谷氨酸能突触，比如海马，杏仁核,伏隔核,和尾状核.结构协方差网络(SCN)分析表明,左侧整个海马体及其子场,与稳定的MCI参与者相比，左整个杏仁核及其亚核显示出明显更强的协方差，MCI回复器中的几个高认知相关大脑区域，这可能有助于说明PGS-C保护作用的潜在神经机制。
