PDF(Pubmed)
Abstract：
Uterine fibroids, benign tumors originating from uterine smooth muscle cells, vary in prevalence depending on patient ethnicity, hormonal exposure, and genetics. Due to their high incidence, these neoplasms pose a significant burden on healthcare systems. Current treatment strategies range from routine monitoring in asymptomatic cases to surgical procedures such as myomectomy or hysterectomy in symptomatic patients, with an increasing trend toward uterus-preserving or non-surgical alternatives. This review examines the existing medical treatments for uterine fibroids and delves into the potential of emerging therapies. A scoping review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Medical therapies are divided into hormonal and non-hormonal treatments; however, long-term, safe, and effective treatments in the treatment of uterine fibroids are limited. In addition to established therapies, there is an increasing number of studies investigating the effect of substances such as vitamin D or green tea extract on uterine fibroids. Some studies investigate acupuncture as a possible alternative therapy. While existing treatments offer symptomatic relief and preparation for surgery, our findings point to a significant need for further research into long-term solutions, especially owing to recent limitations in the use of ulipristal acetate due to risk of liver damage. Initial studies involving vitamin D and epigallocatechin gallate are encouraging; however, additional research is required to establish definitive therapeutic roles.
摘要：
子宫肌瘤,起源于子宫平滑肌细胞的良性肿瘤，患病率因患者种族而异，荷尔蒙暴露，和遗传学。由于其发病率高,这些肿瘤给医疗保健系统带来了巨大的负担。目前的治疗策略从无症状病例的常规监测到有症状患者的子宫肌瘤切除术或子宫切除术等外科手术。随着保留子宫或非手术替代方案的增加趋势。这篇综述研究了现有的子宫肌瘤治疗方法，并探讨了新兴疗法的潜力。根据系统审查的首选报告项目和范围审查的荟萃分析扩展对文献进行范围审查。医学疗法分为激素疗法和非激素疗法；然而，长期的,安全,子宫肌瘤的有效治疗方法有限。除了既定的疗法，研究维生素D或绿茶提取物等物质对子宫肌瘤的影响的研究越来越多。一些研究探讨针灸作为一种可能的替代疗法。虽然现有的治疗方法可以缓解症状并为手术做准备，我们的发现表明，需要进一步研究长期解决方案，特别是由于最近由于肝损害的风险而限制了醋酸乌利司他的使用。涉及维生素D和表没食子儿茶素没食子酸酯的初步研究令人鼓舞；然而，需要更多的研究来确定明确的治疗作用.
