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Abstract：
BACKGROUND: An elevated neutrophil-to-lymphocyte ratio (NLR) in peripheral blood is an independent prognostic indicator of various cancers.
OBJECTIVE: In this study, we aimed to investigate the prognostic relevance of the intratumoral immune cell balance in gastric cancer.
RESULTS: The study included 82 patients who underwent curative resection for gastric cancer. The intratumoral cluster of differentiation (CD) 15- and CD8-positive cells were evaluated using immunohistochemical staining. Additionally, clinicopathological factors and prognoses were analyzed. Patients with high intratumoral CD15/CD8 ratios had significantly lower overall survival (OS) and relapse-free survival (RFS) compared to those with low CD15/CD8 ratios (p = .0026 and p < .0001, respectively). Additionally, a high CD15/CD8 ratio was associated with lymph node metastasis (p = .019). Patients with high NLR had a significantly lower RFS than those with low NLR (p = .0050). Multivariate analysis revealed that the intratumoral CD15/CD8 ratio, NLR, and venous invasion were independent prognostic indicators of RFS (CD15/CD8 ratio: p < .001, hazard ratio (HR) = 14.7, 95% confidence interval (CI) = 3.8-56.8; NLR: p = .010, HR = 5.4, 95% CI = 1.5-19.6; venous invasion: p = .005, HR = 7.4, 95% CI = 1.8-29.7).
CONCLUSIONS: In summary, we found that the intratumoral CD15/CD8 ratio is an independent prognostic factor following gastric cancer resection and its increase is associated with lymph node metastasis and microscopic lymph vessel invasion. Immunological evaluation with additional aspects of innate immunity may be useful in predicting cancer prognosis.
OBJECTIVE: In this study, we aimed to investigate the prognostic relevance of the intratumoral immune cell balance in gastric cancer.
RESULTS: The study included 82 patients who underwent curative resection for gastric cancer. The intratumoral cluster of differentiation (CD) 15- and CD8-positive cells were evaluated using immunohistochemical staining. Additionally, clinicopathological factors and prognoses were analyzed. Patients with high intratumoral CD15/CD8 ratios had significantly lower overall survival (OS) and relapse-free survival (RFS) compared to those with low CD15/CD8 ratios (p = .0026 and p < .0001, respectively). Additionally, a high CD15/CD8 ratio was associated with lymph node metastasis (p = .019). Patients with high NLR had a significantly lower RFS than those with low NLR (p = .0050). Multivariate analysis revealed that the intratumoral CD15/CD8 ratio, NLR, and venous invasion were independent prognostic indicators of RFS (CD15/CD8 ratio: p < .001, hazard ratio (HR) = 14.7, 95% confidence interval (CI) = 3.8-56.8; NLR: p = .010, HR = 5.4, 95% CI = 1.5-19.6; venous invasion: p = .005, HR = 7.4, 95% CI = 1.8-29.7).
CONCLUSIONS: In summary, we found that the intratumoral CD15/CD8 ratio is an independent prognostic factor following gastric cancer resection and its increase is associated with lymph node metastasis and microscopic lymph vessel invasion. Immunological evaluation with additional aspects of innate immunity may be useful in predicting cancer prognosis.
摘要：
背景：外周血中性粒细胞与淋巴细胞比率（NLR）升高是各种癌症的独立预后指标。
目的：在本研究中，我们旨在探讨肿瘤内免疫细胞平衡与胃癌预后的相关性。
结果：本研究包括82例胃癌根治术患者。使用免疫组织化学染色评估肿瘤内分化簇(CD)15-和CD8-阳性细胞。此外,分析临床病理因素和预后。与低CD15/CD8比率的患者相比，肿瘤内CD15/CD8比率高的患者的总生存率（OS）和无复发生存率（RFS）显着降低（分别为p=.0026和p<.0001）。此外,高CD15/CD8比值与淋巴结转移相关(p=0.019).高NLR患者的RFS明显低于低NLR患者（p=.0050）。多因素分析显示，肿瘤内CD15/CD8比值，NLR,和静脉浸润是RFS的独立预后指标（CD15/CD8比值：p<.001，风险比（HR）=14.7，95％置信区间（CI）=3.8-56.8；NLR：p=.010，HR=5.4，95％CI=1.5-19.6；静脉浸润：p=.005，HR=7.4，95％CI=1.8-29.7）。
结论：总之，我们发现肿瘤内CD15/CD8比值是胃癌切除术后的独立预后因素,其升高与淋巴结转移和微血管浸润相关.具有先天免疫的其他方面的免疫学评估可用于预测癌症预后。
目的：在本研究中，我们旨在探讨肿瘤内免疫细胞平衡与胃癌预后的相关性。
结果：本研究包括82例胃癌根治术患者。使用免疫组织化学染色评估肿瘤内分化簇(CD)15-和CD8-阳性细胞。此外,分析临床病理因素和预后。与低CD15/CD8比率的患者相比，肿瘤内CD15/CD8比率高的患者的总生存率（OS）和无复发生存率（RFS）显着降低（分别为p=.0026和p<.0001）。此外,高CD15/CD8比值与淋巴结转移相关(p=0.019).高NLR患者的RFS明显低于低NLR患者（p=.0050）。多因素分析显示，肿瘤内CD15/CD8比值，NLR,和静脉浸润是RFS的独立预后指标（CD15/CD8比值：p<.001，风险比（HR）=14.7，95％置信区间（CI）=3.8-56.8；NLR：p=.010，HR=5.4，95％CI=1.5-19.6；静脉浸润：p=.005，HR=7.4，95％CI=1.8-29.7）。
结论：总之，我们发现肿瘤内CD15/CD8比值是胃癌切除术后的独立预后因素,其升高与淋巴结转移和微血管浸润相关.具有先天免疫的其他方面的免疫学评估可用于预测癌症预后。
