Abstract：
Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase-dependent apoptosis. However, emerging evidence suggests that caspase-independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase-dependent apoptotic pathways potentially in a pathway-dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein-coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine. This article is categorized under: RNA in Disease and Development > RNA in Disease.
摘要：
细胞死亡在各种生理和病理过程中起着至关重要的作用。直到最近,程序性细胞死亡主要归因于caspase依赖性细胞凋亡。然而,新出现的证据表明，caspase非依赖性细胞死亡（CICD）机制也显著有助于细胞死亡。我们和其他人已经报道并在功能上表征了许多长链非编码RNA（lncRNA），这些RNA可能以途径依赖性方式调节胱天蛋白酶依赖性凋亡途径。然而,lncRNAs和CICD通路之间的相互作用尚未得到全面的记录.其中一个主要原因是最近发现了大多数CI-CD途径，其中一些途径在分子水平上被部分表征。在这次审查中,我们讨论了在CICD的调控和执行中涉及特定lncRNAs的新证据。我们总结了lncRNAs调节不同形式的CICD的不同机制，包括铁性凋亡,坏死,突起，和其他人。此外，我们强调了涉及lncRNAs的复杂调控网络，蛋白质编码基因，以及在健康和疾病中使用CICD的信号通路。了解CICD中lncRNAs的分子机制和功能意义可能会揭示各种疾病的新治疗靶点和诊断工具。为疾病管理和个性化医疗的创新策略铺平道路。本文分为：疾病和发育中的RNA>疾病中的RNA。
