Abstract：
OBJECTIVE: This review sought to define the emerging roles of urinary tumor DNA (utDNA) for diagnosis, monitoring, and treatment of bladder cancer. Building from early landmark studies the focus is on recent studies, highlighting how utDNA could aid personalized care.
RESULTS: Recent research underscores the potential for utDNA to be the premiere biomarker in bladder cancer due to the constant interface between urine and tumor. Many studies find utDNA to be more informative than other biomarkers in bladder cancer, especially in early stages of disease. Points of emphasis include superior sensitivity over traditional urine cytology, broad genomic and epigenetic insights, and the potential for non-invasive, real-time analysis of tumor biology. utDNA shows promise for improving all phases of bladder cancer care, paving the way for personalized treatment strategies. Building from current research, future comprehensive clinical trials will validate utDNA\'s clinical utility, potentially revolutionizing bladder cancer management.
RESULTS: Recent research underscores the potential for utDNA to be the premiere biomarker in bladder cancer due to the constant interface between urine and tumor. Many studies find utDNA to be more informative than other biomarkers in bladder cancer, especially in early stages of disease. Points of emphasis include superior sensitivity over traditional urine cytology, broad genomic and epigenetic insights, and the potential for non-invasive, real-time analysis of tumor biology. utDNA shows promise for improving all phases of bladder cancer care, paving the way for personalized treatment strategies. Building from current research, future comprehensive clinical trials will validate utDNA\'s clinical utility, potentially revolutionizing bladder cancer management.
摘要：
目的：这篇综述试图定义泌尿系肿瘤DNA（utDNA）在诊断中的新兴作用，监测,和膀胱癌的治疗。从早期的地标研究开始，重点是最近的研究，强调utDNA如何帮助个性化护理。
结果：最近的研究强调了由于尿液和肿瘤之间的恒定界面，utDNA可能成为膀胱癌的首要生物标志物。许多研究发现，在膀胱癌中，utDNA比其他生物标志物提供更多信息，尤其是在疾病的早期阶段。重点包括优于传统尿细胞学的敏感性，广泛的基因组和表观遗传见解，以及非侵入性的潜力，肿瘤生物学的实时分析。utDNA显示出改善膀胱癌治疗所有阶段的希望，为个性化治疗策略铺平道路。从目前的研究来看，未来的全面临床试验将验证utDNA的临床实用性，可能彻底改变膀胱癌的管理。
结果：最近的研究强调了由于尿液和肿瘤之间的恒定界面，utDNA可能成为膀胱癌的首要生物标志物。许多研究发现，在膀胱癌中，utDNA比其他生物标志物提供更多信息，尤其是在疾病的早期阶段。重点包括优于传统尿细胞学的敏感性，广泛的基因组和表观遗传见解，以及非侵入性的潜力，肿瘤生物学的实时分析。utDNA显示出改善膀胱癌治疗所有阶段的希望，为个性化治疗策略铺平道路。从目前的研究来看，未来的全面临床试验将验证utDNA的临床实用性，可能彻底改变膀胱癌的管理。
