Abstract：
Few studies have evaluated the association between circulating levels of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and the endocrine disruptor bisphenol A (BPA), with risk of cardiovascular (CV) disease in elderly individuals. This was a cross-sectional study in a subgroup of elderly people from the InCHIANTI Biobank in Italy. We examined the association between circulating serum vitamin D metabolites, 1,25(OH)2D, 25(OH)D, and the endocrine disrupting agent BPA, with an arbitrary CV risk score and the European Society of Cardiology-based 10-year CV risk (SCORE2/SCORE2-OP) using univariate and multiple regression. In 299 individuals, blood samples were tested for serum values of 25(OH)D, 1,25(OH)2D and urinary BPA levels. One hundred eighty individuals (60.2%) were deficient (< 20 ng/ml) in 25(OH)D. Levels of 25(OH)D and 1,25(OH)2D were negatively correlated with CV risk score (p < 0.0001 for both) as well as SCORE2/SCORE2-OP (p < 0.0001 for both) while BPA levels were positively correlated with both CV risk scores (p < 0.0001 for both). In a logistic regression model, male gender (odds ratio; OR: 2.1, 95% CI:1.1-3.8, p = 0.022), obesity (OR:2.8, 95% CI:1.2-6.5, p = 0.016) and BPA levels ≥ 110 ng/dl (OR:20.9, 95% CI:9.4-46.8, p < 0.0001) were associated with deficient levels of 25(OH)D. 1,25(OH)2D levels < 41 ng/dl and 25(OH)D levels < 20 ng/ml were associated with CV risk score ≥ 3 (OR: 4.16, 95% CI: 2.32-7.4, p < 0.0001 and OR: 1.86, 95% CI: 1.02-3.39, p = 0.044) respectively and 1,25(OH)2D levels < 41 ng/dl were associated with SCORE2/SCORE2-OP of ≥ 20% (OR:2.98, 95% CI: 1.7-5.2, p = 0.0001). In this cross-sectional analysis, BPA exposure was associated with significantly reduced levels of vitamin D that in turn were significantly associated with increased CV risk.
摘要：
很少有研究评估25-羟基维生素D（25（OH）D）的循环水平之间的关联，1,25-二羟基维生素D（1,25（OH）2D），和内分泌干扰物双酚A（BPA），老年人患心血管疾病(CV)的风险。这是一项针对意大利InCHIANTIBiobank老年人亚组的横断面研究。我们检查了循环血清维生素D代谢物之间的关联，1,25(OH)2D,25(OH)D,和内分泌干扰剂BPA，使用单变量和多元回归的任意CV风险评分和欧洲心脏病学会基于10年CV风险(SCORE2/SCORE2-OP)。在299个人中，血液样本检测血清25(OH)D值，1,25(OH)2D和尿BPA水平。一百八十个人（60.2％）缺乏25（OH）D（<20ng/ml）。25(OH)D和1,25(OH)2D水平与CV风险评分(两者p<0.0001)以及SCORE2/SCORE2-OP(两者p<0.0001)呈负相关,而BPA水平与两者CV风险评分呈正相关(两者p<0.0001)。在逻辑回归模型中，男性（比值比；OR：2.1，95%CI：1.1-3.8，p=0.022），肥胖（OR：2.8，95％CI：1.2-6.5，p=0.016）和BPA水平≥110ng/dl（OR：20.9，95％CI：9.4-46.8，p<0.0001）与25（OH）D缺乏水平相关。1,25（OH）2D水平<41ng/dl和25（OH）D水平<20ng/ml与CV风险评分≥3相关（OR：4.16，95％CI：2.32-7.4，p<0.0001和OR：1.86，95％CI：1.02-3.39，p=0.044）和1,25（OH）2D水平<41ng/dl与SCORE2/SCORE01-OP相关：在这个横截面分析中，BPA暴露与维生素D水平显着降低相关，而维生素D水平又与CV风险增加显着相关。
