Abstract：
OBJECTIVE: Recommendations on the use of nonsugar sweeteners are contradictory, even if they come from official sources. The aim is to review and discuss recent findings on the potential impact of nonsugar sweeteners on human health.
RESULTS: While randomized controlled trials (RCTs) with short duration and risk factors endpoints mostly show favourable effects on body weight and cardiometabolic parameters when nonsugar sweeteners are used to replaced sugar-sweetened products, observational studies mostly show a positive association between the consumption of nonsugar sweeteners and cardiometabolic diseases. The conflicting results may be explained by the heterogenous nature of nonsugar sweeteners but also likely is a consequence of serious weaknesses of available studies.
CONCLUSIONS: For more evidence-based recommendations for practice and policy, scientifically sound studies with long follow-up are required.
RESULTS: While randomized controlled trials (RCTs) with short duration and risk factors endpoints mostly show favourable effects on body weight and cardiometabolic parameters when nonsugar sweeteners are used to replaced sugar-sweetened products, observational studies mostly show a positive association between the consumption of nonsugar sweeteners and cardiometabolic diseases. The conflicting results may be explained by the heterogenous nature of nonsugar sweeteners but also likely is a consequence of serious weaknesses of available studies.
CONCLUSIONS: For more evidence-based recommendations for practice and policy, scientifically sound studies with long follow-up are required.
摘要：
目的：关于使用非糖甜味剂的建议是矛盾的，即使他们来自官方来源。目的是回顾和讨论有关非糖甜味剂对人类健康的潜在影响的最新发现。
结果：虽然具有短持续时间和风险因素终点的随机对照试验（RCT）大多显示，当使用非糖甜味剂替代含糖产品时，对体重和心脏代谢参数有有利影响。观察性研究大多表明，食用非糖甜味剂与心脏代谢疾病之间存在正相关。矛盾的结果可以通过非糖甜味剂的异质性来解释，但也可能是现有研究严重弱点的结果。
结论：有关更多基于证据的实践和政策建议，需要进行科学的、长期随访的研究。
结果：虽然具有短持续时间和风险因素终点的随机对照试验（RCT）大多显示，当使用非糖甜味剂替代含糖产品时，对体重和心脏代谢参数有有利影响。观察性研究大多表明，食用非糖甜味剂与心脏代谢疾病之间存在正相关。矛盾的结果可以通过非糖甜味剂的异质性来解释，但也可能是现有研究严重弱点的结果。
结论：有关更多基于证据的实践和政策建议，需要进行科学的、长期随访的研究。
