PDF(Pubmed)
Abstract：
Objectives: Exploring the relationship between the hOGG1 rs1052133 polymorphism and the occurrence of nasopharyngeal carcinoma (NPC). Methods: PubMed, Web of Science, Scopus, CNKI, Wanfangdata, and VIP were used to search for studies and the NOS evaluation scale was used to evaluate the quality. All studies were grouped according to different genotypes. The Cochrane\'s Q test and I2 test were used for heterogeneity evaluations. If heterogeneity was small, the fixed effects model was used, and conversely, the random effects model was used. Publication bias was also detected. P < .05 in all results indicated statistically significant. Results: We ultimately included 6 studies with 2021 NPC patients in the study group and 2375 healthy populations in the control group. After meta-analysis, it was found that the total OR value of the \"Ser/Cys (CG) vs Ser/Ser (CC)\" group was 1.00 (95% CI: 0.85-1.18) and the \"Cys/Cys (GG) vs Ser/Ser (CC)\" group was 1.06 (95% CI: 0.87-1.28). These results were not statistically significant (P > .05). Furthermore, the integrated total OR values of each group were not statistically significant with or without the smoking history, even in other genotype models (Allele, Dominant, Recessive, and Additive) (P > .05). Conclusion: There is no clear correlation between the hOGG1 rs1052133 polymorphism and the occurrence of NPC, even with or without the smoking history.
摘要：
目的：探讨hOGG1rs1052133多态性与鼻咽癌（NPC）发生的关系。方法:PubMed,WebofScience,Scopus,CNKI,Wanfangdata,和VIP用于搜索研究，NOS评估量表用于评估质量。所有研究都根据不同的基因型进行分组。采用Cochrane的Q检验和I2检验进行异质性评价。如果异质性很小，使用固定效应模型，反过来,采用随机效应模型。还检测到出版偏倚。所有结果的P<.05表明有统计学意义。结果：我们最终纳入了6项研究，研究组为2021例NPC患者，对照组为2375例健康人群。经过荟萃分析，发现“Ser/Cys（CG）vsSer/Ser（CC）”组的总OR值为1.00（95％CI：0.85-1.18），“Cys/Cys（GG）vsSer/Ser（CC）”组为1.06（95％CI：0.87-1.28）。这些结果无统计学意义(P>.05)。此外，在有或没有吸烟史的情况下，每组的综合总OR值均无统计学意义，即使在其他基因型模型中(等位基因，占主导地位，隐性,和添加剂)(P>.05)。结论:hOGG1rs1052133多态性与鼻咽癌的发生无明显相关性,即使有或没有吸烟史。
