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Abstract：
Background Of liver-related disorders, cirrhosis is currently the leading cause of death and has become a significant global public health concern. Aspartate aminotransferase to platelet ratio index (APRI), a newer prognostic modality, is a very effective noninvasive diagnostic for identifying advanced liver fibrosis. Methods A prospective observational study was conducted among individuals with liver disease, 100 cases and 100 controls for two years. All the sociodemographic details, clinical features of the patients, and clinical findings such as prothrombin time (PT), liver function tests, kidney function tests, and total blood count were recorded using a pretested semi-structured questionnaire. Results According to our survey results, 48% of the participants were between the ages of 40 and 60. Regarding aPTT (activated partial thromboplastin time) and liver function test characteristics (serum glutamic-oxaloacetic transaminase(SGOT), serum glutamic pyruvic transaminase (SGPT)), we showed a substantial difference between the patients and controls. Regarding the APRI distribution, we also found a statistically significant variation between the research groups. When we compared the validity of APRI scores in diagnosing cirrhosis, we discovered that the ideal cutoff value of APRI was determined to be 3.99, with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 33%, 86%, 70%, and 56%, respectively. The area under the receiver operating characteristic (ROC) curve for APRI in detecting cirrhosis was also 0.693. Conclusion Thus, our study results conclude that APRI is a crucial noninvasive prognostic tool that can be utilized to prognostize liver cirrhosis.
摘要：
肝脏相关疾病的背景，肝硬化是目前死亡的主要原因,已成为全球重大公共卫生问题.天冬氨酸转氨酶与血小板比值指数(APRI),一种较新的预后模式，是一种非常有效的非侵入性诊断，用于识别晚期肝纤维化。方法在肝病患者中进行了一项前瞻性观察研究，100个病例和100个对照，为期两年。所有的社会人口统计细节，患者的临床特征，和临床发现，如凝血酶原时间（PT），肝功能检查,肾功能测试,使用预先测试的半结构化问卷记录总血细胞计数.结果根据我们的调查结果,48％的参与者年龄在40至60岁之间。关于aPTT（活化部分凝血活酶时间）和肝功能测试特征（血清谷草转氨酶（SGOT），血清谷丙转氨酶（SGPT），我们发现患者和对照组之间存在显著差异.关于APRI的分布，我们还发现研究组之间的差异具有统计学意义.当我们比较APRI评分诊断肝硬化的有效性时，我们发现APRI的理想截断值被确定为3.99，具有灵敏度，特异性，阳性预测值(PPV)，阴性预测值(NPV)为33%，86%,70%,56%,分别。APRI检测肝硬化的受试者工作特征（ROC）曲线下面积也为0.693。结论因此，我们的研究结果得出结论,APRI是一种重要的非侵入性预后工具,可用于预测肝硬化.
