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Abstract：
The identification of recurrent genomic alterations in tumour cells has a significant role in the classification of mature B- and T-cell lymphomas. Following the development of new technologies, such as next generation sequencing and the improvement of classical technologies such as conventional and molecular cytogenetics, a huge catalogue of genomic alterations in lymphoid neoplasms has been established. These alterations are relevant to refine the taxonomy of the classification of lymphomas, to scrutinize the differential diagnosis within different lymphoma entities and to help assessing the prognosis and clinical management of the patients. Consequently, here we describe the key genetic alterations relevant in mature B- and T-cell lymphomas.
摘要：
肿瘤细胞中复发性基因组改变的鉴定在成熟B和T细胞淋巴瘤的分类中具有重要作用。随着新技术的发展，例如下一代测序和传统和分子细胞遗传学等经典技术的改进，已经建立了一个巨大的淋巴肿瘤基因组改变目录。这些改变与完善淋巴瘤分类的分类学有关，仔细检查不同淋巴瘤实体的鉴别诊断，并帮助评估患者的预后和临床管理。因此,在这里,我们描述了与成熟B细胞和T细胞淋巴瘤相关的关键遗传改变.
