PDF(Pubmed)
Abstract：
Aripiprazole has been linked to the development of impulse control problems (ICPs), most commonly gambling. Aripiprazole\'s effect on serotonergic and dopaminergic pathways has had mixed results on drinking behaviors. A male patient receiving outpatient psychiatric care presented with ongoing symptoms of depression on his current regimen of mirtazapine and gabapentin. Aripiprazole was chosen for augmentation after multiple failed trials of alternative medications. Within 3 weeks the patient discontinued the medication due to escalating binge-drinking behavior. This behavior resolved within 3 days after discontinuing aripiprazole. Individuals who engage in binge drinking demonstrate consistent impulse control deficits that are unrelated to the rewarding effects of alcohol. Aripiprazole may be related to this patient\'s return to binge drinking from an ICP standpoint rather than driven by alcohol cravings as other psychosocial factors remained stable throughout this time.
摘要：
阿立哌唑与冲动控制问题（ICPs）的发展有关，最常见的赌博。阿立哌唑对5-羟色胺能和多巴胺能途径的影响对饮酒行为有不同的结果。一名接受门诊精神病治疗的男性患者在目前的米氮平和加巴喷丁治疗方案中表现出持续的抑郁症状。在多个替代药物试验失败后，选择阿立哌唑用于增强。在3周内，由于暴饮暴食行为的升级，患者停止了药物治疗。这种行为在停用阿立哌唑后3天内消失。暴饮暴食的个人表现出一致的冲动控制缺陷，这与酒精的有益效果无关。从ICP的角度来看，阿立哌唑可能与该患者的暴饮暴食有关，而不是由于其他社会心理因素在这段时间内保持稳定。
