PDF(Pubmed)
Abstract：
It is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways, suggesting that macrophages can perform different functions through metabolic reprogramming. It is now gradually recognized that lactate, previously overlooked as a byproduct of glycolytic metabolism, acts as a signaling molecule in regulating multiple biological processes, including immunological responses and metabolism. Recently, lactate has been found to mediate epigenetic changes in macrophages through a newfound lactylation modification, thereby regulating their phenotypic transformation. This novel finding highlights the significant role of lactate metabolism in macrophage function. In this review, we summarize the features of relevant metabolic reprogramming in macrophages and the role of lactate metabolism therein. We also review the progress of research on the regulation of macrophage metabolic reprogramming by lactylation through epigenetic mechanisms.
摘要：
众所周知，不同的巨噬细胞表型在不同的病理生理过程中起着特定的作用。近年来,许多研究已经将巨噬细胞的表型与其在不同代谢途径中的特征联系起来，表明巨噬细胞可以通过代谢重编程执行不同的功能。现在逐渐认识到乳酸，以前被忽视作为糖酵解代谢的副产品，在调节多个生物过程中充当信号分子，包括免疫反应和新陈代谢。最近,已发现乳酸通过新发现的乳酸化修饰介导巨噬细胞的表观遗传变化，从而调节它们的表型转化。这个新发现强调了乳酸代谢在巨噬细胞功能中的重要作用。在这次审查中,我们总结了巨噬细胞中相关代谢重编程的特征以及乳酸代谢在其中的作用。我们还综述了通过表观遗传机制通过乳酸化调节巨噬细胞代谢重编程的研究进展。
