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Abstract：
Mixed germ cell tumors (mGCTs) involving both the ovaries and sellar region have been rarely reported; thus, they pose significant challenges in clinical management. Our report of a case of a 26-year-old female with left ovarian mGCTs (dysgerminoma + yolk sac tumor) who presented with postoperative headaches and blurred vision contributes new information to the literature on treating mGCTs, which can lead to standardized regimens and sequencing guidelines. A physical examination revealed right temporal hemianopia, and elevated levels of alpha-fetoprotein were detected in serum and cerebrospinal fluid. Magnetic resonance imaging (MRI) of the sellar region revealed a space-occupying lesion. Pathological examination of the tumor after endoscopic transnasal resection confirmed the diagnosis of mGCTs (germinomas + yolk sac tumor). The patient received adjuvant chemotherapy and radiotherapy at reduced dosages. During follow-up, tumor markers remained within normal limits, and there was no evidence of tumor recurrence on sellar region MRI. This case highlights the rarity of the simultaneous occurrence of ovarian and sellar region mGCTs and emphasizes the importance of accurate diagnosis and multidisciplinary management.
摘要：
涉及卵巢和鞍区的混合性生殖细胞肿瘤（mGCT）很少报道；因此，它们对临床管理构成了重大挑战.我们报告了一例26岁的女性，患有左卵巢mGCT（无性细胞瘤卵黄囊瘤），其术后头痛和视力模糊，为治疗mGCT的文献提供了新的信息。这可以导致标准化的方案和测序指南。体格检查显示右颞叶偏盲,血清和脑脊液中检测到甲胎蛋白水平升高。鞍区的磁共振成像（MRI）显示出占位病变。经鼻内镜切除术后的肿瘤病理检查证实了mGCT（生殖细胞瘤卵黄囊瘤）的诊断。患者接受减少剂量的辅助化疗和放疗。随访期间,肿瘤标志物保持在正常范围内，鞍区MRI没有肿瘤复发的证据。该病例突出了同时发生卵巢和鞍区mGCT的罕见性，并强调了准确诊断和多学科管理的重要性。
