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Abstract：
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally, colorectal cancer has been recognized as a disease caused by genetic mutations. However, recent studies have revealed the significant role of epigenetic alterations in the progression of colorectal cancer. Epithelial-mesenchymal transition, a critical step in cancer cell metastasis, has been found to be closely associated with the tumor microenvironment and immune factors, thereby playing a crucial role in many kinds of biological behaviors of cancers. In this review, we explored the impact of N6-methyladenosine and post-translational modifications (like methylation, acetylation, ubiquitination, SUMOylation, glycosylation, etc.) on the process of epithelial-mesenchymal transition in colorectal cancer and the epigenetic regulation for the transcription factors and pathways correlated to epithelial-mesenchymal transition. Furthermore, we emphasized that the complex regulation of epithelial-mesenchymal transition by epigenetics can provide new strategies for overcoming drug resistance and improving treatment outcomes. This review aims to provide important scientific evidence for the prevention and treatment of colorectal cancer based on epigenetic modifications.
摘要：
结直肠癌是全球癌症相关死亡率的主要原因。传统上,结直肠癌已被认为是由基因突变引起的疾病。然而,最近的研究揭示了表观遗传改变在结直肠癌进展中的重要作用.上皮-间质转化,癌细胞转移的关键步骤，已发现与肿瘤微环境和免疫因素密切相关,从而在癌症的多种生物学行为中起着至关重要的作用。在这次审查中,我们探索了N6-甲基腺苷和翻译后修饰的影响(如甲基化，乙酰化,泛素化，SUMOylation,糖基化，等。）关于结直肠癌中上皮-间质转化的过程以及与上皮-间质转化相关的转录因子和途径的表观遗传调控。此外，我们强调,表观遗传学对上皮-间质转化的复杂调控可以为克服耐药性和改善治疗结局提供新策略.本文旨在为基于表观遗传修饰的结直肠癌的预防和治疗提供重要的科学依据。
