PDF(Pubmed)
Abstract：
Acute Respiratory Distress Syndrome (ARDS) is a critical form of Acute Lung Injury (ALI), challenging clinical diagnosis and severity assessment. This study evaluates the potential utility of various hematological markers in burn-mediated ARDS, including Neutrophil-to-Lymphocyte Ratio (NLR), Mean Platelet Volume (MPV), MPV-to-Lymphocyte Ratio (MPVLR), Platelet count, and Platelet Distribution Width (PDW). Employing a retrospective analysis of data collected over 12 years, this study focuses on the relationship between these hematological markers and ARDS diagnosis and severity in hospitalized patients. The study establishes NLR as a reliable systemic inflammation marker associated with ARDS severity. Elevated MPV and MPVLR also emerged as significant markers correlating with adverse outcomes. These findings suggest these economical, routinely measured markers can enhance traditional clinical criteria, offering a more objective approach to ARDS diagnosis and severity assessment. Hematological markers such as NLR, MPV, MPVLR, Platelet count, and PDW could be invaluable in clinical settings for diagnosing and assessing ARDS severity. They offer a cost-effective, accessible means to improve diagnostic accuracy and patient stratification in ARDS. However, further prospective studies are necessary to confirm these findings and investigate their integration with other diagnostic tools in diverse clinical settings.
摘要：
急性呼吸窘迫综合征（ARDS）是急性肺损伤（ALI）的一种重要形式，具有挑战性的临床诊断和严重程度评估。这项研究评估了各种血液学标志物在烧伤介导的ARDS中的潜在用途，包括中性粒细胞与淋巴细胞比率（NLR），平均血小板体积（MPV），MPV与淋巴细胞比率（MPVLR），血小板计数,和血小板分布宽度（PDW）。对12年来收集的数据进行回顾性分析，本研究的重点是这些血液学指标与住院患者ARDS诊断和严重程度之间的关系.该研究将NLR确立为与ARDS严重程度相关的可靠的全身性炎症标志物。MPV和MPVLR升高也是与不良结局相关的重要标志物。这些发现表明这些经济，常规测量的标志物可以增强传统的临床标准，为ARDS诊断和严重程度评估提供了更客观的方法。血液学标志物，如NLR，MPV,MPVLR,血小板计数,和PDW在诊断和评估ARDS严重程度的临床设置中可能是非常宝贵的。他们提供了一个具有成本效益的，提高ARDS诊断准确性和患者分层的方法。然而,需要进一步的前瞻性研究来证实这些发现,并在不同的临床环境中研究它们与其他诊断工具的整合.
