Abstract：
OBJECTIVE: This study aimed to evaluate the effect of Astragalus root extract on nurses suffering from post-COVID-19 chronic fatigue syndrome.
METHODS: The study was designed as a triple-blind, randomised, controlled trial in Iran in 2023. 64 chronic fatigue syndrome nurses were randomly assigned to one of two groups: an intervention group (n=32) that received Astragalus root extract (500 mg two times per day) or a control group (n=32) that received a placebo. Changes in chronic fatigue syndrome scores were measured before to, at the end of and 1 month after the intervention. Data were analysed using descriptive and analytical statistics (T-tests, χ2, analysis of variances, Cochran\'s Q tests, McNemar and generalised estimating equations).
RESULTS: In comparison to before, chronic fatigue prevalence decreased statistically significantly at the end of the intervention group (13.8%) and 1 month later (17.2%). Further, the frequency differed between before and after (p=0.0001) and 1 month later (p=0.0001). In the control group, chronic fatigue was statistically significantly different before and after the intervention (72.2%; p=0.003). Having an underlying disease (B=0.84, OR=2.33; p=0.04) and being in the control group (B=2.15, OR=12.36; p=0.01) increased the risk of chronic fatigue, whereas increasing the length of time decreased it (B=-0.67, OR=0.50; p=0.0001).
CONCLUSIONS: Astragalus root extract has been shown to reduce chronic fatigue in nurses. Therefore, this herbal extract can be used to reduce the incidence and treatment of chronic fatigue in nurses.
METHODS: The study was designed as a triple-blind, randomised, controlled trial in Iran in 2023. 64 chronic fatigue syndrome nurses were randomly assigned to one of two groups: an intervention group (n=32) that received Astragalus root extract (500 mg two times per day) or a control group (n=32) that received a placebo. Changes in chronic fatigue syndrome scores were measured before to, at the end of and 1 month after the intervention. Data were analysed using descriptive and analytical statistics (T-tests, χ2, analysis of variances, Cochran\'s Q tests, McNemar and generalised estimating equations).
RESULTS: In comparison to before, chronic fatigue prevalence decreased statistically significantly at the end of the intervention group (13.8%) and 1 month later (17.2%). Further, the frequency differed between before and after (p=0.0001) and 1 month later (p=0.0001). In the control group, chronic fatigue was statistically significantly different before and after the intervention (72.2%; p=0.003). Having an underlying disease (B=0.84, OR=2.33; p=0.04) and being in the control group (B=2.15, OR=12.36; p=0.01) increased the risk of chronic fatigue, whereas increasing the length of time decreased it (B=-0.67, OR=0.50; p=0.0001).
CONCLUSIONS: Astragalus root extract has been shown to reduce chronic fatigue in nurses. Therefore, this herbal extract can be used to reduce the incidence and treatment of chronic fatigue in nurses.
摘要：
目的：本研究旨在评估黄芪提取物对COVID-19后慢性疲劳综合征护士的影响。
方法：该研究设计为三盲，随机化，2023年在伊朗进行对照试验。64名慢性疲劳综合征护士被随机分为两组：接受黄芪根提取物（每天两次500mg）的干预组（n=32）或接受安慰剂的对照组（n=32）。在去之前测量慢性疲劳综合征评分的变化，在干预结束后和1个月。使用描述性和分析性统计学对数据进行分析(T检验，χ2，方差分析，Cochran的Q测试,McNemar和广义估计方程)。
结果：与之前相比，慢性疲劳患病率在干预组结束时(13.8%)和1个月后(17.2%)显著下降.Further,频率在前后（p=0.0001）和1个月后（p=0.0001）之间有所不同。在对照组中，慢性疲劳干预前后差异有统计学意义(72.2%;p=0.003)。患有潜在疾病（B=0.84，OR=2.33;p=0.04）和对照组（B=2.15，OR=12.36;p=0.01）会增加慢性疲劳的风险，而时间长度的增加则减少（B=-0.67，OR=0.50；p=0.0001）。
结论：黄芪提取物已被证明可以减轻护士的慢性疲劳。因此,这种草药提取物可用于减少护士慢性疲劳的发生率和治疗。
方法：该研究设计为三盲，随机化，2023年在伊朗进行对照试验。64名慢性疲劳综合征护士被随机分为两组：接受黄芪根提取物（每天两次500mg）的干预组（n=32）或接受安慰剂的对照组（n=32）。在去之前测量慢性疲劳综合征评分的变化，在干预结束后和1个月。使用描述性和分析性统计学对数据进行分析(T检验，χ2，方差分析，Cochran的Q测试,McNemar和广义估计方程)。
结果：与之前相比，慢性疲劳患病率在干预组结束时(13.8%)和1个月后(17.2%)显著下降.Further,频率在前后（p=0.0001）和1个月后（p=0.0001）之间有所不同。在对照组中，慢性疲劳干预前后差异有统计学意义(72.2%;p=0.003)。患有潜在疾病（B=0.84，OR=2.33;p=0.04）和对照组（B=2.15，OR=12.36;p=0.01）会增加慢性疲劳的风险，而时间长度的增加则减少（B=-0.67，OR=0.50；p=0.0001）。
结论：黄芪提取物已被证明可以减轻护士的慢性疲劳。因此,这种草药提取物可用于减少护士慢性疲劳的发生率和治疗。
