Abstract：
Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1), also known as capsaicin receptor, in 1997 was a milestone achievement in the research on temperature sensation and pain signalling. Very soon after it became evident that TRPV1 is implicated in a wide array of physiological processes in different peripheral tissues, as well as in the central nervous system, and thereby could be involved in the pathophysiology of numerous diseases. Increasing evidence suggests that modulation of TRPV1 may also affect seizure susceptibility and epilepsy. This channel is localized in brain regions associated with seizures and epilepsy, and its overexpression was found both in animal models of seizures and in brain samples from epileptic patients. Moreover, modulation of TRPV1 on non-neuronal cells (microglia, astrocytes, and/or peripheral immune cells) may have an impact on the neuroinflammatory processes that play a role in epilepsy and epileptogenesis. In this paper, we provide a comprehensive and critical overview of currently available data on TRPV1 as a possible molecular target for epilepsy management, trying to identify research gaps and future directions. Overall, several converging lines of evidence implicate TRPV1 channel as a potentially attractive target in epilepsy research but more studies are needed to exploit the possible role of TRPV1 in seizures/epilepsy and to evaluate the value of TRPV1 ligands as candidates for new antiseizure drugs.
摘要：
识别瞬时受体电位阳离子通道，亚家族V成员1（TRPV1），也被称为辣椒素受体，1997年是温度感觉和疼痛信号研究的里程碑成就。很明显，TRPV1参与了不同外周组织的一系列广泛的生理过程，以及中枢神经系统，从而可能参与许多疾病的病理生理学。越来越多的证据表明，TRPV1的调节也可能影响癫痫发作易感性和癫痫。该通道位于与癫痫发作和癫痫相关的大脑区域，在癫痫的动物模型和癫痫患者的脑样本中都发现了它的过度表达。此外，TRPV1对非神经元细胞(小胶质细胞，星形胶质细胞,和/或外周免疫细胞）可能对在癫痫和癫痫发生中起作用的神经炎过程产生影响。在本文中,我们提供了关于TRPV1作为癫痫治疗可能的分子靶标的现有数据的全面和关键概述,试图找出研究差距和未来方向。总的来说,一些证据表明TRPV1通道是癫痫研究中潜在的有吸引力的靶标,但需要更多的研究来利用TRPV1在癫痫发作/癫痫发作中的可能作用,并评估TRPV1配体作为新型抗癫痫药物候选药物的价值.
