Abstract：
Give the emergence of drug resistance in bacteria resulting from antibiotic misuse, there is an urgent need for research and application of novel antibacterial approaches. In recent years, nanoparticles (NPs) have garnered significant attention due to their potential to disrupt bacteria cellular structure through loading drugs and special mechanisms, thus rendering them inactive. In this study, the surface of hollow polydopamine (HPDA) NPs was utilized for the growth of Prussian blue (PB), resulting in the formation of HPDA-PB NPs. Incorporation of Co element during the preparation process led to partial doping of PB with Co2+ions. The performance test results demonstrated that the HPDA-PB NPs exhibited superior photothermal conversion efficiency and peroxidase-like activity compared to PB NPs. HPDA-PB NPs have the ability to catalyze the formation of hydroxyl radicals from H2O2in a weakly acidic environment. Due to the tiny PB particles on the surface and the presence of Co2+doping, they have strong broad-spectrum antibacterial properties. Bothin vitroandin vivoevaluations confirm their efficacy against various bacterial strains, particularlyStaphylococcus aureus, and their potential to promote wound healing, making them a promising candidate for advanced wound care and antimicrobial applications.
摘要：
给抗生素滥用引起的细菌耐药性的出现，迫切需要新型抗菌方法的研究和应用。近年来,纳米颗粒由于其通过加载药物和特殊机制破坏细菌细胞结构的潜力而引起了极大的关注，从而使他们变得不活跃。在这项研究中,中空聚多巴胺纳米颗粒的表面用于普鲁士蓝（PB）的生长，导致HPDA-PBNP的形成。在制备过程中掺入Co元素导致PB被Co2离子部分掺杂。性能测试结果表明，与PBNP相比，HPDA-PBNP表现出优异的光热转化效率和POD样活性。HPDA-PB纳米颗粒具有在弱酸性环境中催化H2O2形成羟基自由基的能力。由于表面上的小PB颗粒和Co2掺杂的存在，它们具有很强的广谱抗菌性能。体外和体内评估都证实了它们对各种细菌菌株的功效，特别是金黄色葡萄球菌，以及它们促进伤口愈合的潜力，使它们成为高级伤口护理和抗菌应用的有希望的候选者。
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