Abstract：
This research aimed to develop a novel, effective, and stable delivery system based on zein (ZE), sodium caseinate (SC), and quaternary ammonium chitosan (HACC) for curcumin (CUR). The pH-driven self-assembly combined with electrostatic deposition methods were employed to construct CUR-loaded ZE-SC nanoparticles with HACC coating (ZE-SC@HACC). The optimized nanocomposite was prepared at ZE:SC:HACC:CUR mass ratios of 1:1:2:0.1, and it had encapsulation efficiency of 89.3%, average diameter of 218.2 nm, and ζ-potential of 40.7 mV. The assembly of composites and encapsulation of CUR were facilitated primarily by hydrophobic, hydrogen-bonding, and electrostatic interactions. Physicochemical stability analysis revealed that HACC coating dramatically enhanced ZE-SC nanoparticles\' colloidal stability and CUR\'s resistance to chemical degradation. Additionally, antioxidant activity and simulated digestion results indicated that CUR-ZE-SC@HACC nanoparticles showed higher free radical scavenging capacity and bio-accessibility of CUR than CUR-ZE-SC nanoparticles and free CUR. Therefore, the ZE-SC@HACC nanocomposite is an effective and viable delivery system for CUR.
摘要：
这项研究旨在开发一部小说，有效,和基于玉米醇溶蛋白(ZE)的稳定递送系统，酪蛋白酸钠（SC），和季铵壳聚糖（HACC）为姜黄素（CUR）。pH驱动的自组装结合静电沉积方法来构建具有HACC涂层(ZE-SC@HACC)的加载CUR的ZE-SC纳米颗粒。以ZE:SC:HACC:CUR质量比为1:1:2:0.1制备优化的纳米复合材料,包封率为89.3%,平均直径为218.2nm，和ζ电位为40.7mV。复合材料的组装和CUR的封装主要通过疏水促进，氢键,和静电相互作用。物理化学稳定性分析表明，HACC涂层显着增强了ZE-SC纳米粒子的胶体稳定性和CUR的耐化学降解性。此外,抗氧化活性和模拟消化结果表明，CUR-ZE-SC@HACC纳米颗粒比CUR-ZE-SC纳米颗粒和游离CUR具有更高的自由基清除能力和生物可达性。因此,ZE-SC@HACC纳米复合材料是CUR的有效和可行的递送系统。
