METHODS: This was a post hoc analysis of the enrollment and follow-up data from the Human Epilepsy Project, an international, multi-institutional study that enrolled participants between 2012 and 2017. Participants enrolled were 11-17 years of age within 4 months of treatment initiation for focal epilepsy. We used data from the Columbia Suicide Severity Rating Scale (C-SSRS), administered at enrollment and over the 36-month follow-up period, along with data from medical records.
RESULTS: A total of 66 adolescent participants were enrolled and completed the C-SSRS. At enrollment, 14 (21%) had any lifetime SI and 5 (8%) had any lifetime suicidal behaviors (SBs). Over the following 36 months, 6 adolescents reported new onset SI and 5 adolescents reported new onset SB. Thus, the lifetime prevalence of SI within this population increased from 21% to 30% (14-20 adolescents), and the lifetime prevalence of SB increased from 8% to 15% (5-10).
CONCLUSIONS: The prevalence of suicidality in adolescents with newly diagnosed focal epilepsy reported in our study is consistent with previous findings of significant suicidality observed in epilepsy. We identify adolescents as an at-risk population at the time of epilepsy diagnosis and in the following years.
方法:这是对人类癫痫项目的登记和随访数据的事后分析,一个国际,2012年至2017年招募参与者的多机构研究。招募的参与者年龄为11-17岁,在局灶性癫痫治疗开始后4个月内。我们使用了哥伦比亚自杀严重程度评定量表(C-SSRS)的数据,在登记时和36个月的随访期内进行,还有医疗记录中的数据.
结果:共有66名青少年参与者入组并完成了C-SSRS。在入学时,14人(21%)有终身SI,5人(8%)有终身自杀行为(SB)。在接下来的36个月里,6名青少年报告新发SI,5名青少年报告新发SB。因此,该人群中SI的终生患病率从21%增加到30%(14-20名青少年),SB的终生患病率从8%增加到15%(5-10)。
结论:我们的研究中报道的青少年新诊断局灶性癫痫的自杀率与先前在癫痫中观察到的显著自杀率的发现是一致的。我们在癫痫诊断时和随后几年将青少年确定为高危人群。