Abstract：
In this study, we investigate the expression of muscle markers, including the specific skeletal muscle markers myogenin and myoD1, in neuroendocrine carcinomas (NECs). The study included 23 NECs from various sites (14 small cell NECs and 9 large cell NECs). These were stained with desmin, myogenin and myoD1. Positive staining with at least one muscle marker was observed in 14 cases (61%). 8 (35%), 8 (35%) and 11 (48%) of the cases were positive with desmin, myogenin and myoD1 respectively. In most, but not all, cases positive staining was focal generally involving < 10% of tumour cells. Expression of muscle markers is not uncommon in NECs. This represents an important diagnostic pitfall of which pathologists should be aware. In reporting this phenomenon, we speculate on the pathogenesis of this \"aberrant\" expression of muscle markers.
摘要：
在这项研究中,我们研究了肌肉标志物的表达，在神经内分泌癌（NECs）中，包括特定的骨骼肌标志物肌原蛋白和myoD1。该研究包括来自不同地点的23个NEC(14个小细胞NEC和9个大细胞NEC)。这些被desmin染色，肌原蛋白和myoD1。在14例（61％）中观察到至少一种肌肉标志物的阳性染色。8（35%），8例(35%)和11例(48%)结蛋白阳性，肌原蛋白和myoD1。在大多数情况下,但不是全部,阳性染色的病例通常是局灶性的，涉及<10％的肿瘤细胞。肌肉标志物的表达在NEC中并不少见。这是病理学家应该意识到的重要诊断缺陷。在报道这一现象时，我们推测这种“异常”表达的肌肉标志物的发病机制。
