PDF(Pubmed)
Abstract：
Hepatocellular carcinoma (HCC), an aggressive malignancy with a dismal prognosis, poses a significant public health challenge. Recent research has highlighted the crucial role of lipid metabolism in HCC development, with enhanced lipid synthesis and uptake contributing to the rapid proliferation and tumorigenesis of cancer cells. Lipids, primarily synthesized and utilized in the liver, play a critical role in the pathological progression of various cancers, particularly HCC. Cancer cells undergo metabolic reprogramming, an essential adaptation to the tumor microenvironment (TME), with fatty acid metabolism emerging as a key player in this process. This review delves into intricate interplay between HCC and lipid metabolism, focusing on four key areas: de novo lipogenesis, fatty acid oxidation, dysregulated lipid metabolism of immune cells in the TME, and therapeutic strategies targeting fatty acid metabolism for HCC treatment.
摘要：
肝细胞癌（HCC），预后不佳的侵袭性恶性肿瘤，构成了重大的公共卫生挑战。最近的研究强调了脂质代谢在肝癌发展中的关键作用，增强的脂质合成和摄取有助于癌细胞的快速增殖和肿瘤发生。脂质,主要在肝脏中合成和利用，在各种癌症的病理进展中起关键作用，特别是HCC。癌细胞经历代谢重编程，对肿瘤微环境（TME）的基本适应，随着脂肪酸代谢成为这个过程中的关键参与者。这篇综述深入探讨了肝癌和脂质代谢之间复杂的相互作用，重点关注四个关键领域：从头脂肪生成，脂肪酸氧化，TME中免疫细胞的脂质代谢失调，以及针对脂肪酸代谢的肝癌治疗策略。
