Abstract：
BACKGROUND: The routine clinical practice is to prioritize the transfer of blastocysts derived from 2PN embryos if they are available. For women who only have blastocysts resulting from 0PN and 1PN embryos, whether to transfer these embryos or discard them has been an ongoing debate over the years.
OBJECTIVE: To investigate the perinatal and obstetric outcomes following the transfer of vitrified-warmed single blastocysts derived from 0PN and 1PN zygotes.
METHODS: Retrospective cohort study.
METHODS: University-affiliated IVF center.
METHODS: This study included singletons born to women who had undergone 0PN and 1PN vitrified-warmed single blastocyst transfers, compared to those resulting from 2PN vitrified-warmed single blastocyst transfers from 2012 to 2020.
METHODS: None.
METHODS: Perinatal and obstetric outcomes.
RESULTS: A total of 7,284 women were included in the final analysis. Of these, 386, 316, and 6582 cycles resulted from 0PN-, 1PN-, and 2PN-derived blastocysts transfer, respectively. The rates of clinical pregnancy, miscarriage, and live birth were similar across the study cohorts in both unadjusted and adjusted analyses. When comparing the 0PN and 2PN groups, no differences were found in birth outcomes after adjusting for confounders. Similarly, maternal complications and mode of delivery were comparable between these two study cohorts. Birth parameters were also similar between the 1PN and 2PN blastocyst groups, except for more male births in the 1PN cohort. Furthermore, a comparison between the 1PN and 2PN groups did not reveal any significant differences in maternal outcomes.
CONCLUSIONS: The current study showed that the transfer of 0PN and 1PN blastocysts did not compromise reproductive outcomes or increase maternal and perinatal complications. This information is valuable for clinicians to counsel couples effectively and guide them in making informed decisions.
OBJECTIVE: To investigate the perinatal and obstetric outcomes following the transfer of vitrified-warmed single blastocysts derived from 0PN and 1PN zygotes.
METHODS: Retrospective cohort study.
METHODS: University-affiliated IVF center.
METHODS: This study included singletons born to women who had undergone 0PN and 1PN vitrified-warmed single blastocyst transfers, compared to those resulting from 2PN vitrified-warmed single blastocyst transfers from 2012 to 2020.
METHODS: None.
METHODS: Perinatal and obstetric outcomes.
RESULTS: A total of 7,284 women were included in the final analysis. Of these, 386, 316, and 6582 cycles resulted from 0PN-, 1PN-, and 2PN-derived blastocysts transfer, respectively. The rates of clinical pregnancy, miscarriage, and live birth were similar across the study cohorts in both unadjusted and adjusted analyses. When comparing the 0PN and 2PN groups, no differences were found in birth outcomes after adjusting for confounders. Similarly, maternal complications and mode of delivery were comparable between these two study cohorts. Birth parameters were also similar between the 1PN and 2PN blastocyst groups, except for more male births in the 1PN cohort. Furthermore, a comparison between the 1PN and 2PN groups did not reveal any significant differences in maternal outcomes.
CONCLUSIONS: The current study showed that the transfer of 0PN and 1PN blastocysts did not compromise reproductive outcomes or increase maternal and perinatal complications. This information is valuable for clinicians to counsel couples effectively and guide them in making informed decisions.
摘要：
背景：常规的临床实践是优先考虑移植来自2PN胚胎的胚泡，如果它们可用的话。对于仅具有由0PN和1PN胚胎产生的胚泡的女性，多年来，是否转移这些胚胎或丢弃它们一直是一个持续的争论。
目的：探讨0PN和1PN受精卵来源的玻璃化加温单胚泡移植后的围产期和产科结局。
方法：回顾性队列研究。
方法：大学附属IVF中心。
方法：这项研究包括接受0PN和1PN玻璃化加热单胚泡移植的女性所生的单胎，与2012年至2020年2PN玻璃化升温单胚泡移植产生的结果相比。
方法：无。
方法：围产期和产科结局。
结果：共有7,284名妇女被纳入最终分析。其中,386、316和6582个循环是由0PN-产生的，1PN-,和2PN来源的胚泡转移，分别。临床妊娠率，流产,在未调整和调整的分析中,研究队列中的活产和活产相似.当比较0PN和2PN组时，校正混杂因素后,出生结局无差异.同样，这两个研究队列的产妇并发症和分娩方式具有可比性.1PN和2PN囊胚组的出生参数也相似，除了1PN队列中更多的男性出生。此外，1PN组和2PN组之间的比较未发现产妇结局有任何显著差异.
结论：目前的研究表明，0PN和1PN胚泡的转移并不影响生殖结局或增加母体和围产期并发症。这些信息对于临床医生有效地为夫妻提供咨询并指导他们做出明智的决定是有价值的。
目的：探讨0PN和1PN受精卵来源的玻璃化加温单胚泡移植后的围产期和产科结局。
方法：回顾性队列研究。
方法：大学附属IVF中心。
方法：这项研究包括接受0PN和1PN玻璃化加热单胚泡移植的女性所生的单胎，与2012年至2020年2PN玻璃化升温单胚泡移植产生的结果相比。
方法：无。
方法：围产期和产科结局。
结果：共有7,284名妇女被纳入最终分析。其中,386、316和6582个循环是由0PN-产生的，1PN-,和2PN来源的胚泡转移，分别。临床妊娠率，流产,在未调整和调整的分析中,研究队列中的活产和活产相似.当比较0PN和2PN组时，校正混杂因素后,出生结局无差异.同样，这两个研究队列的产妇并发症和分娩方式具有可比性.1PN和2PN囊胚组的出生参数也相似，除了1PN队列中更多的男性出生。此外，1PN组和2PN组之间的比较未发现产妇结局有任何显著差异.
结论：目前的研究表明，0PN和1PN胚泡的转移并不影响生殖结局或增加母体和围产期并发症。这些信息对于临床医生有效地为夫妻提供咨询并指导他们做出明智的决定是有价值的。
