PDF(Pubmed)
Abstract：
Oral submucous fibrosis (OSMF) has a high rate of malignant transformation and is an insidious chronic inflammatory disease. Though this disorder seems to be multifactorial in origin, betel quid chewing appears to be the main etiologic factor. Various treatment strategies have been attempted but none proven to cure the disorder because of its multimodal pathogenesis. Reactive oxygen species (ROS) appear to have a role in cancer formation. As OSMF is an oral premalignant disorder and found to be associated with carcinogens like areca nut and tobacco, it is believed to have some relationship with ROS. Tissue damage due to ROS along with other mechanisms may result in the complex pathophysiology of OSMF. The antioxidant system in the body helps to prevent damage caused by highly reactive ROS and helps in the repair of tissues. To study the levels of oxidative stress and antioxidant vitamins in OSMF condition, the present review was done. We carried out a thorough literature search to identify original reports and studies determining the status of oxidative stress and antioxidant vitamins in OSMF condition using several databases including Google Scholar, PubMed, and Scopus. Our review observed that the oxidative stress increased in the condition of OSMF as shown by an increase in malonaldehyde (MDA) and a decrease in antioxidant vitamins like vitamin A, vitamin C, and vitamin E. Also, after the intake of antioxidant vitamins, there was symptomatic improvement in OSMF patients. With the help of identifying oxidative stress and antioxidant status, we can assess the clinical stage of OSMF and can develop a comprehensive treatment plan.
摘要：
口腔粘膜下纤维化(OSMF)恶变率高,是一种隐匿的慢性炎症性疾病。尽管这种疾病似乎是多方面的，槟榔咀嚼似乎是主要的病因。已尝试了各种治疗策略，但由于其多模态发病机理，均未证明可治愈该疾病。活性氧（ROS）似乎在癌症形成中起作用。由于OSMF是一种口腔癌前疾病，被发现与槟榔和烟草等致癌物有关，它被认为与ROS有一定的关系。由于ROS以及其他机制导致的组织损伤可能导致OSMF的复杂病理生理学。体内的抗氧化系统有助于防止由高反应性ROS引起的损伤，并有助于组织的修复。为了研究OSMF条件下的氧化应激和抗氧化维生素的水平，目前的审查已经完成。我们进行了彻底的文献检索，以确定原始报告和研究确定OSMF条件下的氧化应激和抗氧化维生素的状态使用几个数据库，包括谷歌学者，PubMed,还有Scopus.我们的综述观察到，在OSMF的条件下，氧化应激增加，如丙二醛（MDA）的增加和抗氧化剂维生素如维生素A的减少所示，维生素C,还有维生素E,摄入抗氧化维生素后，OSMF患者症状改善.在识别氧化应激和抗氧化状态的帮助下，我们可以评估OSMF的临床阶段，并可以制定综合治疗方案。
