UNASSIGNED: This was a retrospective study, and after excluding patients with adenomyosis, endometriosis, severe endometrial adhesions, polycystic ovary syndrome (PCOS), and repeated embryo implantation failures, a total of 4,091 HRT cycles were collected. Patients were divided into group A (<35 years old) and group B (≥35 years old), and each group was further divided into HRT and GnRHa-HRT groups. The clinical outcomes were compared between groups.
UNASSIGNED: There was no statistically significant difference in clinical outcomes between the HRT and GnRHa-HRT groups among women aged <35 years. In women of advanced age, higher rates of clinical pregnancy and live birth were seen in the GnRHa-HRT group. Logistic regression analysis showed that female age and number of embryos transferred influenced the live birth rate in FET cycles, and in women aged ≥ 35 years, the use of GnRH-a down-regulation prior to HRT improved pregnancy outcomes.
UNASSIGNED: In elderly woman without adenomyosis, endometriosis, PCOS, severe uterine adhesions, and RIF, hormone replacement treatment with GnRH agonist for pituitary suppression can improve the live birth rate of FET cycles.
■这是一项回顾性研究,排除子宫腺肌病患者后,子宫内膜异位症,严重的子宫内膜粘连,多囊卵巢综合征(PCOS),反复的胚胎植入失败,共收集4,091个HRT周期。将患者分为A组(<35岁)和B组(≥35岁),每组再分为HRT和GnRHa-HRT组。比较两组的临床疗效。
■在年龄<35岁的女性中,HRT组和GnRHa-HRT组的临床结果无统计学差异。在高龄女性中,GnRHa-HRT组的临床妊娠率和活产率较高.Logistic回归分析显示,女性年龄和胚胎移植数量影响FET周期活产率,在35岁以上的女性中,在HRT前使用GnRH-a下调可改善妊娠结局.
■在没有子宫腺肌病的老年女性中,子宫内膜异位症,PCOS,严重的宫腔粘连,RIF,GnRH激动剂用于垂体抑制的激素替代治疗可以提高FET周期的活产率。